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Tylenol (Acetaminophen)

University of Nebraska · FDA-approved active Small molecule

Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system.

Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system. Used for Mild to moderate pain, Fever reduction.

At a glance

Generic nameTylenol (Acetaminophen)
Also known asTylenol
SponsorUniversity of Nebraska
Drug classAnalgesic and antipyretic
TargetCyclooxygenase (COX), primarily central nervous system isoforms
ModalitySmall molecule
Therapeutic areaPain Management
PhaseFDA-approved

Mechanism of action

Acetaminophen is believed to work primarily through inhibition of cyclooxygenase (COX) enzymes in the brain and spinal cord, reducing prostaglandin production and thereby lowering the pain threshold and resetting the body's temperature set point. Unlike NSAIDs, it has minimal peripheral anti-inflammatory effects and does not significantly inhibit COX in peripheral tissues, which accounts for its different safety profile.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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