Last reviewed 2026-04-23 · How we verify

Tritanrix™-HepB Kft

Tritanrix-HepB is a combination vaccine that provides immunization against diphtheria, tetanus, pertussis, and hepatitis B through simultaneous administration of inactivated toxoids and recombinant hepatitis B surface antigen.

Tritanrix-HepB is a combination vaccine that provides immunization against diphtheria, tetanus, pertussis, and hepatitis B through simultaneous administration of inactivated toxoids and recombinant hepatitis B surface antigen. Used for Primary immunization against diphtheria, tetanus, pertussis, and hepatitis B in infants and children.

At a glance

Mechanism of action

The vaccine contains diphtheria and tetanus toxoids (inactivated bacterial toxins) that stimulate antibody production against these toxins, acellular pertussis antigens that trigger immune responses to Bordetella pertussis, and recombinant hepatitis B surface antigen (HBsAg) that elicits protective antibodies against hepatitis B virus. Together, these components induce humoral and cellular immune responses that provide protection against all four pathogens.

Approved indications

• Primary immunization against diphtheria, tetanus, pertussis, and hepatitis B in infants and children

Common side effects

• Injection site reactions (pain, redness, swelling)
• Fever
• Irritability
• Drowsiness

Key clinical trials

• Immune Response Post Pry Vaccination of 2 Formulations of DTPw-HBV Vaccine Given With Rotavirus Vaccine to Infants (PHASE3)
• Immune Memory of DTPw-HBV/Hib Vaccine Following Primary Vaccination, Immuno & Reacto of a Booster Dose Given in Infants (PHASE3)
• Non-inferiority of GSK Biologicals' DTPw-HBV/Hib Compared to Two Formulations of GSK Biologicals' DTPw-HBV/Hib (PHASE3)
• Assess Immunogenicity, Reactogenicity, Safety of a Booster of GSK Biologicals DTPw-HBV/Hib Kft Compared to DTPw-HBV/Hib (PHASE3)

Primary sources

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