Last reviewed 2026-04-23 · How we verify

Triclosan toothpaste

Triclosan toothpaste works by inhibiting the growth of bacteria in the mouth.

Triclosan toothpaste works by inhibiting the growth of bacteria in the mouth. Used for Prevention of gingivitis and plaque formation.

At a glance

Mechanism of action

Triclosan is an antibacterial agent that targets the cell membranes of bacteria, ultimately leading to their death. This action helps to reduce the formation of plaque and prevent gingivitis. Regular use of triclosan toothpaste can contribute to a healthier oral microbiome.

Approved indications

• Prevention of gingivitis and plaque formation

Common side effects

• Gingivitis
• Tooth sensitivity
• Oral irritation

Key clinical trials

• Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque
• Effectiveness of a Triclosan Containing Toothpaste in Maintaining Periodontal Health in a Type 2 Diabetic Population (PHASE3)
• Dentifrice With Innovative Remineralizing Technology (NA)
• Meta-analysis of Stannous Fluoride and the Effects on Gingival Health
• Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste (PHASE4)
• The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis (PHASE2)
• Clinical Investigation of the Effects of Colgate Total Toothpaste as Compared to a Matching Placebo on Periodontal Disease and Systemic Inflammatory Markers (PHASE4)
• Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. (PHASE4)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.