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Triclosan, Fluoride
Triclosan, Fluoride is a Small molecule drug developed by Colgate Palmolive. It is currently FDA-approved. Also known as: Total+ Whitening toothpaste, triclosan/fluoride/copolymer toothpaste, Total toothpaste, Colgate Total toothpaste.
Triclosan is a small molecule that acts as an inhibitor of the bacterial enzyme enoyl-[acyl-carrier-protein] reductase, specifically targeting FabI. It is used in toothpaste, often in combination with fluoride, to help prevent conditions such as dental plaque, gingivitis, and periodontal diseases.
At a glance
| Generic name | Triclosan, Fluoride |
|---|---|
| Also known as | Total+ Whitening toothpaste, triclosan/fluoride/copolymer toothpaste, Total toothpaste, Colgate Total toothpaste, Colgate Total Advanced Freshening toothpaste |
| Sponsor | Colgate Palmolive |
| Modality | Small molecule |
| Phase | FDA-approved |
Approved indications
Common side effects
Key clinical trials
- Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque
- Effectiveness of a Triclosan Containing Toothpaste in Maintaining Periodontal Health in a Type 2 Diabetic Population (PHASE3)
- Dentifrice With Innovative Remineralizing Technology (NA)
- Meta-analysis of Stannous Fluoride and the Effects on Gingival Health
- Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste (PHASE4)
- The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis (PHASE2)
- Clinical Investigation of the Effects of Colgate Total Toothpaste as Compared to a Matching Placebo on Periodontal Disease and Systemic Inflammatory Markers (PHASE4)
- Periodontal Treatment Response in Type II Diabetic Patients
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Triclosan, Fluoride CI brief — competitive landscape report
- Triclosan, Fluoride updates RSS · CI watch RSS
- Colgate Palmolive portfolio CI
Frequently asked questions about Triclosan, Fluoride
What is Triclosan, Fluoride?
Who makes Triclosan, Fluoride?
Is Triclosan, Fluoride also known as anything else?
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Related
- Manufacturer: Colgate Palmolive — full pipeline
- Also known as: Total+ Whitening toothpaste, triclosan/fluoride/copolymer toothpaste, Total toothpaste, Colgate Total toothpaste, Colgate Total Advanced Freshening toothpaste
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing