Last reviewed · How we verify
tribulus terrestris
Tribulus terrestris is a plant extract that may enhance nitric oxide production and improve vascular function, potentially increasing blood flow and sexual performance.
Tribulus terrestris is a plant extract that may enhance nitric oxide production and improve vascular function, potentially increasing blood flow and sexual performance. Used for Erectile dysfunction, Sexual dysfunction in women, Athletic performance enhancement.
At a glance
| Generic name | tribulus terrestris |
|---|---|
| Also known as | tribulus, lot 168059 |
| Sponsor | Federal University of Minas Gerais |
| Drug class | Herbal supplement / Plant extract |
| Modality | Small molecule |
| Therapeutic area | Sexual dysfunction / Urology |
| Phase | FDA-approved |
Mechanism of action
The active compounds in Tribulus terrestris, particularly saponins, are believed to stimulate nitric oxide synthase and increase nitric oxide availability in endothelial cells. This leads to vasodilation and improved blood flow. The extract has also been studied for potential effects on testosterone levels and sexual function, though evidence remains mixed.
Approved indications
- Erectile dysfunction
- Sexual dysfunction in women
- Athletic performance enhancement
Common side effects
- Gastrointestinal upset
- Headache
- Insomnia
- Breast tenderness
Key clinical trials
- Integrative Liver-Targeted Therapy for Diabetic Macular Edema: Combining Tauroursodeoxycholate and Traditional Chinese Medicine. (PHASE2)
- Acute Effects of Tribulus Terrestris on Anaerobic Power and Sprint Performance in Combat Sport Athletes (NA)
- Efficacy and Safety Study of Products Based on Tribulus Terrestris, L. in Men With Oligospermia (PHASE4)
- Combining Chinese Medicine and Nutrition to Enhance Weight Loss After Bariatric Surgery (NA)
- Study to Evaluate the Effectiveness and Safety of Libicare® in Women With Low Arousal and Sexual Desire Levels (NA)
- Clinical Efficacy of Crano-cure inTreatment of Urinary Tract Infection (NA)
- Clinical Trial to Investigate the Effectiveness of a Dietary Supplement in Increasing Libido and Sexual Function in Postmenopausal Women. (NA)
- Effects of Tribulus Terrestris in Women With Hypoactive Sexual Desire Disorder (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |