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Triamcinolone + Lidocaine
Triamcinolone reduces inflammation via glucocorticoid receptor activation, while lidocaine provides local anesthetic effects by blocking sodium channels in nerve fibers.
Triamcinolone reduces inflammation via glucocorticoid receptor activation, while lidocaine provides local anesthetic effects by blocking sodium channels in nerve fibers. Used for Intra-articular injection for inflammatory joint conditions, Intralesional injection for inflammatory skin conditions, Local infiltration for pain and inflammation relief.
At a glance
| Generic name | Triamcinolone + Lidocaine |
|---|---|
| Also known as | Kenalog = Triamcinolone |
| Sponsor | MetroHealth Medical Center |
| Drug class | Corticosteroid + Local anesthetic combination |
| Target | Glucocorticoid receptor (triamcinolone); voltage-gated sodium channels (lidocaine) |
| Modality | Small molecule |
| Therapeutic area | Rheumatology / Pain Management / Dermatology |
| Phase | FDA-approved |
Mechanism of action
Triamcinolone is a synthetic corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Lidocaine is a local anesthetic that blocks voltage-gated sodium channels, preventing nerve depolarization and pain signal transmission. Together, this combination provides both anti-inflammatory and analgesic effects at the site of injection.
Approved indications
- Intra-articular injection for inflammatory joint conditions
- Intralesional injection for inflammatory skin conditions
- Local infiltration for pain and inflammation relief
Common side effects
- Local injection site reactions (pain, swelling, erythema)
- Transient systemic corticosteroid effects
- Allergic reaction to lidocaine
- Infection at injection site
Key clinical trials
- USG-Guided Shoulder Injections in Frozen Shoulder (NA)
- Bladder Directed vs. Pelvic Floor Therapy in IC/BPS (PHASE2)
- Microneedling for Burn Hypertrophic Scars (NA)
- Knee Injections for Obese Patients With Knee Arthritis (PHASE4)
- A Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (ActiveMatrix) Verses Standard of Care in Adhesive Capsulitis of the Shoulder (PHASE4)
- Efficacy of Triamcinolone-Lidocaine Mix in Trigger Points Injection of Masseter Muscle: Double-blinded, Randomized Controlled Trial (PHASE2, PHASE3)
- Bone Marrow Aspirate Concentrate Versus Triamcinolone Injection For Hip Osteoarthritis (PHASE3)
- The Effect of Local Corticosteroid Injection in Carpal Tunnel Syndrome Patients With Type 2 Diabetes
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |