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Tri-luma
Tri-Luma is a topical combination that inhibits melanin production and reduces hyperpigmentation through multiple mechanisms including tyrosinase inhibition and corticosteroid activity.
Tri-Luma is a topical combination that inhibits melanin production and reduces hyperpigmentation through multiple mechanisms including tyrosinase inhibition and corticosteroid activity. Used for Melasma (chloasma).
At a glance
| Generic name | Tri-luma |
|---|---|
| Sponsor | Hexsel Dermatology Clinic |
| Drug class | Topical depigmenting agent combination |
| Target | Tyrosinase; retinoic acid receptor; glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Tri-Luma contains hydroquinone (a tyrosinase inhibitor that blocks melanin synthesis), tretinoin (a retinoid that increases cell turnover and reduces pigment deposition), and fluocinolone acetonide (a corticosteroid that reduces inflammation and melanin production). Together, these three agents work synergistically to lighten hyperpigmented areas of skin.
Approved indications
- Melasma (chloasma)
Common side effects
- Skin irritation
- Erythema
- Desquamation
- Burning sensation
- Photosensitivity
Key clinical trials
- Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Light (IPL) in Melasma (PHASE4)
- Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for Melasma (PHASE4)
- Comparison of Two Tri-Luma® Maintenance Regimens in the Treatment of Melasma (PHASE4)
- A Fixed Triple Combination Cream for Solar Lentigines Associated to Cryotherapy (NA)
- Solar Lentigines Treatment With the Triple Combination Cream (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tri-luma CI brief — competitive landscape report
- Tri-luma updates RSS · CI watch RSS
- Hexsel Dermatology Clinic portfolio CI