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Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab
Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab is a Combination immunosuppressive and anti-TNF therapy Small molecule drug developed by University of Helsinki. It is currently FDA-approved for Rheumatoid arthritis, Inflammatory bowel disease. Also known as: Trexan, Salazopyrin, Oxiklorin, Prednison, Remicade.
This combination therapy suppresses inflammatory and immune responses through multiple mechanisms including methotrexate-induced immunosuppression, sulfasalazine's anti-inflammatory effects, corticosteroid action, and TNF-alpha inhibition via infliximab.
This combination therapy suppresses inflammatory and immune responses through multiple mechanisms including methotrexate-induced immunosuppression, sulfasalazine's anti-inflammatory effects, corticosteroid action, and TNF-alpha inhibition via infliximab. Used for Rheumatoid arthritis, Inflammatory bowel disease.
At a glance
| Generic name | Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab |
|---|---|
| Also known as | Trexan, Salazopyrin, Oxiklorin, Prednison, Remicade |
| Sponsor | University of Helsinki |
| Drug class | Combination immunosuppressive and anti-TNF therapy |
| Target | Multiple: dihydrofolate reductase (methotrexate), TNF-alpha (infliximab), glucocorticoid receptor (prednisolone) |
| Modality | Small molecule |
| Therapeutic area | Immunology / Rheumatology |
| Phase | FDA-approved |
Mechanism of action
Trexan (methotrexate) inhibits dihydrofolate reductase and suppresses T-cell proliferation. Salazopyrin (sulfasalazine) reduces intestinal inflammation and modulates immune function. Prednisolone is a corticosteroid that broadly suppresses inflammation. Infliximab is a TNF-alpha inhibitor monoclonal antibody that blocks a key pro-inflammatory cytokine. Together, these agents target multiple pathways in inflammatory and autoimmune disease.
Approved indications
- Rheumatoid arthritis
- Inflammatory bowel disease
Common side effects
- Infection (including serious infections)
- Bone marrow suppression
- Hepatotoxicity
- Gastrointestinal disturbance
- Immunosuppression-related complications
Key clinical trials
- Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis (PHASE3)
- TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab CI brief — competitive landscape report
- Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab updates RSS · CI watch RSS
- University of Helsinki portfolio CI
Frequently asked questions about Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab
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Related
- Drug class: All Combination immunosuppressive and anti-TNF therapy drugs
- Target: All drugs targeting Multiple: dihydrofolate reductase (methotrexate), TNF-alpha (infliximab), glucocorticoid receptor (prednisolone)
- Manufacturer: University of Helsinki — full pipeline
- Therapeutic area: All drugs in Immunology / Rheumatology
- Indication: Drugs for Rheumatoid arthritis
- Indication: Drugs for Inflammatory bowel disease
- Also known as: Trexan, Salazopyrin, Oxiklorin, Prednison, Remicade
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