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Treated Dentin Matrix
Treated Dentin Matrix is a bioactive scaffold derived from demineralized dentin that promotes regeneration of dental tissues through delivery of bioactive molecules and structural support.
Treated Dentin Matrix is a bioactive scaffold derived from demineralized dentin that promotes regeneration of dental tissues through delivery of bioactive molecules and structural support. Used for Dentin-pulp complex regeneration, Endodontic treatment and periapical lesion repair, Dental tissue regeneration.
At a glance
| Generic name | Treated Dentin Matrix |
|---|---|
| Sponsor | Ain Shams University |
| Drug class | Tissue engineering scaffold / Regenerative biomaterial |
| Modality | Small molecule |
| Therapeutic area | Dentistry / Regenerative Medicine |
| Phase | Phase 3 |
Mechanism of action
Dentin matrix contains growth factors and proteins that are released upon demineralization, stimulating odontoblast differentiation and dentin-pulp complex regeneration. The matrix serves as both a biological signal and a structural scaffold for new tissue formation, facilitating repair of dental defects and endodontic lesions.
Approved indications
- Dentin-pulp complex regeneration
- Endodontic treatment and periapical lesion repair
- Dental tissue regeneration
Common side effects
Key clinical trials
- Comparative Evaluation of Calcium Silicate-doped Treated Dentin Matrix and Mineral Trioxide Aggregate as Miniature Pulpotomy Biomaterials in Deep Carious Lesions (NA)
- Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation (NA)
- Evaluation of Regenerative Endodontic Treatment for Immature Teeth (NA)
- Clinical and Radiographic Evaluation of Three Biomimetic Materials in Pulp Therapy of Immature Young Permanent Teeth "A Randomized Controlled Clinical Trial" (PHASE3)
- Tomographic Evaluation of Pulpotomy in Young Permanent Teeth Using Human-treated Dentin Matrix (PHASE1, PHASE2)
- Evaluation of Apexogenesis With Human Treated Dentin Matrix in Young Permanent Molars (PHASE1, PHASE2)
- Therapeutic Irrigation Procedures to Treat Apical Periodontitis (NA)
- Treated Dentine Matrix and Platelet Rich Fibrin in Induction of Root Formation of Non-Vital Immature Permanent Teeth (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Treated Dentin Matrix CI brief — competitive landscape report
- Treated Dentin Matrix updates RSS · CI watch RSS
- Ain Shams University portfolio CI