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total intravenous anesthetics
Total intravenous anesthetics are a class of drugs that induce and maintain general anesthesia by depressing the central nervous system through enhancement of GABAergic inhibitory neurotransmission.
Total intravenous anesthetics are a class of drugs that induce and maintain general anesthesia by depressing the central nervous system through enhancement of GABAergic inhibitory neurotransmission. Used for Induction and maintenance of general anesthesia, Sedation in intensive care units.
At a glance
| Generic name | total intravenous anesthetics |
|---|---|
| Sponsor | Università Vita-Salute San Raffaele |
| Drug class | GABA-A receptor agonist / General anesthetic |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
These agents work primarily by potentiating gamma-aminobutyric acid (GABA) signaling at GABA-A receptors in the brain, leading to hyperpolarization of neurons and reduced neuronal excitability. Common agents in this class include propofol, etomidate, and ketamine, each with distinct pharmacokinetic profiles and clinical properties. They are administered intravenously to rapidly induce unconsciousness and are often used for induction and maintenance of general anesthesia in surgical and critical care settings.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in intensive care units
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Apnea
Key clinical trials
- Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial (NA)
- Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery (NA)
- Post-Hoc Cost-Utility Analysis of Ultrasound-Guided Erector Spinae Plane (ESP) Block Versus Total Intravenous Anesthesia (TIVA) in Posterior Scoliosis Correction Surgery: Evidence From the Egyptian EQ-5D-5L Value Set
- The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients (NA)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty (PHASE4)
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Hemorrhoid Surgery (NA)
- Supraclavicular Block vs Bier's Block for Forearm Trauma Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- total intravenous anesthetics CI brief — competitive landscape report
- total intravenous anesthetics updates RSS · CI watch RSS
- Università Vita-Salute San Raffaele portfolio CI