Last reviewed 2026-05-13 · How we verify

Topicort Topical Spray

Topicort (desoximetasone) is a topical corticosteroid that reduces inflammation and suppresses immune responses in the skin.

Topicort (desoximetasone) is a topical corticosteroid that reduces inflammation and suppresses immune responses in the skin. Used for Psoriasis, Dermatitis, Eczema.

At a glance

Mechanism of action

Desoximetasone is a potent synthetic corticosteroid that binds to glucocorticoid receptors in skin cells, inhibiting inflammatory mediators and immune cell activation. This reduces erythema, pruritus, and other inflammatory manifestations of dermatological conditions. The spray formulation allows for convenient topical application to affected areas.

Approved indications

• Psoriasis
• Dermatitis
• Eczema
• Other inflammatory skin conditions responsive to topical corticosteroids

Common side effects

• Skin atrophy
• Striae
• Telangiectasia
• Local irritation or burning
• Folliculitis

Key clinical trials

• Topical Scalp Psoriasis Study Evaluating Topicort Topical Spray (PHASE4)
• Topical Psoriasis Study for Patients Receiving Biologic Therapy (PHASE4)
• Adrenal Suppression and Pharmacokinetics of Topicort® Spray, 0.25% in Pediatric Patients With Plaque Psoriasis (PHASE4)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Topicort Topical Spray CI brief — competitive landscape report
• Topicort Topical Spray updates RSS · CI watch RSS
• Psoriasis Treatment Center of Central New Jersey portfolio CI