Last reviewed · How we verify
Topical Zinc Oxide
Zinc oxide forms a physical barrier on the skin surface that reflects and scatters ultraviolet radiation and protects against moisture loss.
Zinc oxide forms a physical barrier on the skin surface that reflects and scatters ultraviolet radiation and protects against moisture loss. Used for Sunscreen and UV protection, Diaper rash and moisture barrier protection, Minor skin irritation and wound protection.
At a glance
| Generic name | Topical Zinc Oxide |
|---|---|
| Sponsor | University of Maryland, Baltimore |
| Drug class | Topical sunscreen / barrier agent |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Zinc oxide is an inorganic compound that acts as a broad-spectrum UV filter, blocking both UVA and UVB rays through reflection and scattering rather than chemical absorption. It also creates an occlusive barrier that reduces transepidermal water loss and has mild astringent and anti-inflammatory properties, making it suitable for protective and therapeutic topical applications.
Approved indications
- Sunscreen and UV protection
- Diaper rash and moisture barrier protection
- Minor skin irritation and wound protection
Common side effects
- Local skin irritation or sensitization
- White cast or residue on skin
Key clinical trials
- Effectiveness of Topical Magnetite Zinc Oxide Composite Nanoparticles in the Management of Oral Potentially Malignant Lesions (EARLY_PHASE1)
- Treatment of Basal Cell Carcinoma (BCC) of the Skin, of the Morpheiform, Infiltrative, and Noduloulcerative Types in Inoperable Patients and Not Suitable for Radiotherapy Using Formulated Methylene Blue (PHASE3)
- Investigation of Effect of Formulated Methylene Blue on Treatment of Squamous Cell Carcinoma Skin Cancer in Inoperable Patients and Not Suitable for Radiotherapy (PHASE3)
- Zinc Oxide VS MEBO (PHASE4)
- Zinc Oxide Versus Petrolatum Following Skin Surgery (EARLY_PHASE1)
- Efficacy of Microneedling With Vitamin C in Performing Gingival Depigmentation (PHASE1, PHASE2)
- The Use of Arnica Montana in the Cicatrization of the Umbilical Cord
- The Effect of Donepezil on Wound Healing (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |