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Topical therapy
Topical therapy applies active pharmaceutical agents directly to the skin or affected surface tissue to deliver localized therapeutic effects.
At a glance
| Generic name | Topical therapy |
|---|---|
| Sponsor | Hillel Yaffe Medical Center |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Topical formulations are designed to penetrate the skin barrier and act on local tissues, avoiding systemic absorption and first-pass metabolism. This route of administration allows for high local drug concentrations while minimizing systemic side effects, making it suitable for dermatological and localized inflammatory conditions.
Approved indications
Common side effects
Key clinical trials
- A Phase 2, Baseline-Controlled Study Evaluating the Safety and Efficacy of PTX-022 (Sirolimus) Topical Gel 3.9% in the Treatment of Cutaneous Venous Malformations (PHASE2)
- Topical Methylene Blue-Photodynamic Therapy (MB-PDT) for Burn Wound Infection (PHASE1, PHASE2)
- Analgesic Efficacy and Safety of Topical VMD-3866 Gel in Management of Pain Induced by Chemotherapy (CIPN) (PHASE2)
- Loteprednol Etabonate Versus Prednisolone Acetate for Anterior Chamber Granulomas (PHASE4)
- Durability of Three Monthly Loading Doses With Faricimab in Treatment-naïve Neovascular Age-related Macular Degeneration
- SELVA: A Phase 3 Study Evaluating QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Microcystic Lymphatic Malformations (PHASE3)
- A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis (PHASE2)
- Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Topical therapy CI brief — competitive landscape report
- Topical therapy updates RSS · CI watch RSS
- Hillel Yaffe Medical Center portfolio CI