Last reviewed 2026-04-23 · How we verify

Topical Dapsone 5% Gel

Topical dapsone reduces inflammation and bacterial colonization in skin lesions through its antimicrobial and anti-inflammatory properties.

Topical dapsone reduces inflammation and bacterial colonization in skin lesions through its antimicrobial and anti-inflammatory properties. Used for Acne vulgaris, Rosacea, Other inflammatory skin conditions.

At a glance

Mechanism of action

Dapsone is a sulfone antimicrobial agent that inhibits bacterial folate synthesis and possesses immunomodulatory effects that reduce neutrophilic inflammation. When formulated as a topical 5% gel, it delivers the drug directly to affected skin areas, minimizing systemic exposure while treating localized inflammatory and infectious skin conditions.

Approved indications

• Acne vulgaris
• Rosacea
• Other inflammatory skin conditions

Common side effects

• Local skin irritation
• Erythema
• Dryness
• Contact dermatitis

Key clinical trials

• Comparison of the Efficacy of Clindamycin Phosphate 1% Gel Versus Once-daily Dapsone 5% Gel in the Treatment of Moderate Acne Vulgaris (PHASE2)
• Effect of New Topical Preparation for Treatment of Acne Vulgaris (PHASE2)
• Use of Dapsone Gel, 5% for Treating Dermatitis Herpetiformis (PHASE4)
• Study to Determine and Compare the Tolerance and Irritation Potential of Topical Acne Medications (PHASE4)
• Study Comparing Test to Aczone 5% and Both to a Placebo Control in the Treatment of Acne Vulgaris (PHASE1)
• Study of Prophylactic Topical Dapsone 5% Gel Versus Moisturizer for Cetuximab-induced Papulopustular (Acneiform) Rash in Patients With mCRC or HNSCC Without Previous or Concurrent RT (PHASE3)
• Trial of Dapsone 5.0% Gel in the Treatment of Acne Vulgaris (PHASE3)
• A Study Comparing Aczone® Plus Differin® Versus Duac® Plus Differin® in Patients With Severe Facial Acne (PHASE4)

Primary sources

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