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Tobramycin + Dexamethasone
Tobramycin + Dexamethasone is a Antibiotic + corticosteroid combination Small molecule drug developed by Umm Al-Qura University. It is currently FDA-approved for Bacterial ocular infections with inflammation, Post-operative ocular inflammation and infection prophylaxis. Also known as: Tobradex.
Tobramycin kills bacteria by inhibiting protein synthesis, while dexamethasone reduces inflammation and immune response.
Tobramycin + Dexamethasone is a small molecule medication. It is used to treat various eye conditions, including cataract, as indicated by ClinicalTrials.gov.
At a glance
| Generic name | Tobramycin + Dexamethasone |
|---|---|
| Also known as | Tobradex |
| Sponsor | Umm Al-Qura University |
| Drug class | Antibiotic + corticosteroid combination |
| Target | Bacterial 30S ribosomal subunit (tobramycin); glucocorticoid receptor (dexamethasone) |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology / Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Tobramycin is an aminoglycoside antibiotic that binds to bacterial ribosomes and prevents protein synthesis, leading to bacterial cell death. Dexamethasone is a corticosteroid that suppresses inflammatory and immune responses by inhibiting cytokine production and immune cell activation. Together, this combination addresses both the infectious and inflammatory components of ocular infections.
Approved indications
- Bacterial ocular infections with inflammation
- Post-operative ocular inflammation and infection prophylaxis
Common side effects
- Ocular irritation or discomfort
- Transient blurred vision
- Allergic conjunctivitis
- Increased intraocular pressure (with prolonged use)
Key clinical trials
- Tobradex as Intracanal Medicament (NA)
- Bromfenac to Reduce Inflammation in Patients With Pseudoexfoliation Syndrome After Cataract Surgery (PHASE4)
- A Comparative Study Between Preservative With Benzalkonium Chloride vs Preservative Free Eye Drops on the Ocular Surface (PHASE4)
- VisuMax Femtosecond Laser Small Incision Lenticule Extraction for the Correction of High Myopia (NA)
- Platelet-rich Fibrin(PRF) Membrane in Ophthalmic Diseases (NA)
- Safety and Efficacy of Thermosensitive Hydroxybutyl Chitosan and 5-fluorouracil Assisted Endoscopic Dacryocystorhinostomy in the Treatment of Chronic Dacryocystitis (PHASE1)
- Two Trabecular Micro-bypass Stents & Postoperative Travoprost to Treat Glaucoma Subjects on Two Hypotensive Agents (PHASE4)
- Micro-Conjunctival Autografting Combined With Amniotic Membrane Transplantation Treating Recurrent Pterygium Trial (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tobramycin + Dexamethasone CI brief — competitive landscape report
- Tobramycin + Dexamethasone updates RSS · CI watch RSS
- Umm Al-Qura University portfolio CI
Frequently asked questions about Tobramycin + Dexamethasone
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Related
- Drug class: All Antibiotic + corticosteroid combination drugs
- Target: All drugs targeting Bacterial 30S ribosomal subunit (tobramycin); glucocorticoid receptor (dexamethasone)
- Manufacturer: Umm Al-Qura University — full pipeline
- Therapeutic area: All drugs in Ophthalmology / Infectious Disease
- Indication: Drugs for Bacterial ocular infections with inflammation
- Indication: Drugs for Post-operative ocular inflammation and infection prophylaxis
- Also known as: Tobradex
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing