Last reviewed 2026-05-27 · How we verify

TM buprenorphine

Indivior Inc. · FDA-approved active Small molecule Under review

TM buprenorphine is a Partial mu-opioid receptor agonist Small molecule drug developed by Indivior Inc.. It is currently FDA-approved for Opioid use disorder (maintenance treatment), Moderate to severe pain. Also known as: suboxone, subutex, belbuca, zubsolv.

Buprenorphine is a partial mu-opioid receptor agonist that binds with high affinity to reduce opioid cravings and withdrawal symptoms while producing a ceiling effect on respiratory depression.

TM buprenorphine is a small molecule that acts as a mu opioid receptor agonist. It is used to treat moderate to severe opioid-use disorder.

At a glance

Generic name	TM buprenorphine
Also known as	suboxone, subutex, belbuca, zubsolv, bunavail
Sponsor	Indivior Inc.
Drug class	Partial mu-opioid receptor agonist
Target	Mu-opioid receptor (OPRM1)
Modality	Small molecule
Therapeutic area	Psychiatry / Addiction Medicine
Phase	FDA-approved

Mechanism of action

Buprenorphine acts as a partial agonist at the mu-opioid receptor, meaning it produces submaximal effects compared to full agonists like morphine. This partial agonism provides analgesia and reduces withdrawal symptoms in opioid-dependent patients while having a built-in safety profile due to a ceiling effect on respiratory depression. The high receptor binding affinity also makes it difficult for other opioids to displace it, reducing the risk of overdose when combined with other substances.

Approved indications

Opioid use disorder (maintenance treatment)
Moderate to severe pain

Common side effects

Headache
Constipation
Nausea
Dizziness
Insomnia
Sweating
Respiratory depression

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

TM buprenorphine CI brief — competitive landscape report
TM buprenorphine updates RSS · CI watch RSS
Indivior Inc. portfolio CI

Frequently asked questions about TM buprenorphine

What is TM buprenorphine?

TM buprenorphine is a Partial mu-opioid receptor agonist drug developed by Indivior Inc., indicated for Opioid use disorder (maintenance treatment), Moderate to severe pain.

How does TM buprenorphine work?

Buprenorphine is a partial mu-opioid receptor agonist that binds with high affinity to reduce opioid cravings and withdrawal symptoms while producing a ceiling effect on respiratory depression.

What is TM buprenorphine used for?

TM buprenorphine is indicated for Opioid use disorder (maintenance treatment), Moderate to severe pain.

Who makes TM buprenorphine?

TM buprenorphine is developed and marketed by Indivior Inc. (see full Indivior Inc. pipeline at /company/indivior-inc).

Is TM buprenorphine also known as anything else?

TM buprenorphine is also known as suboxone, subutex, belbuca, zubsolv, bunavail.

What drug class is TM buprenorphine in?

TM buprenorphine belongs to the Partial mu-opioid receptor agonist class. See all Partial mu-opioid receptor agonist drugs at /class/partial-mu-opioid-receptor-agonist.

What development phase is TM buprenorphine in?

TM buprenorphine is FDA-approved (marketed).

What are the side effects of TM buprenorphine?

Common side effects of TM buprenorphine include Headache, Constipation, Nausea, Dizziness, Insomnia, Sweating.

What does TM buprenorphine target?

TM buprenorphine targets Mu-opioid receptor (OPRM1) and is a Partial mu-opioid receptor agonist.

Drug class: All Partial mu-opioid receptor agonist drugs
Target: All drugs targeting Mu-opioid receptor (OPRM1)
Manufacturer: Indivior Inc. — full pipeline
Therapeutic area: All drugs in Psychiatry / Addiction Medicine
Indication: Drugs for Opioid use disorder (maintenance treatment)
Indication: Drugs for Moderate to severe pain
Also known as: suboxone, subutex, belbuca, zubsolv, bunavail

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing