Last reviewed 2026-04-23 · How we verify

Therapeutic Anticoagulation

Therapeutic anticoagulation involves the inhibition of blood clot formation to prevent thrombotic events.

Therapeutic anticoagulation involves the inhibition of blood clot formation to prevent thrombotic events. Used for Prevention of stroke and systemic embolism in non-valvular atrial fibrillation, Treatment and prevention of deep vein thrombosis and pulmonary embolism.

At a glance

Mechanism of action

This is achieved through the modulation of the coagulation cascade, which is a complex process involving multiple enzymes and proteins. Therapeutic anticoagulants work by either inhibiting the production of thrombin or preventing the formation of fibrin clots.

Approved indications

• Prevention of stroke and systemic embolism in non-valvular atrial fibrillation
• Treatment and prevention of deep vein thrombosis and pulmonary embolism

Common side effects

• Major bleeding
• Gastrointestinal bleeding
• Hemorrhage

Key clinical trials

• Short-Term Anticoagulation Versus Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure (PHASE4)
• OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation (PHASE4)
• Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury (NA)
• WATCHMAN FLX Pro European Registry (NA)
• Timing of Venous Thromboembolism Prophylaxis in Patients With Hypertensive Intracerebral Hemorrhage (NA)
• Acupuncture for Preventing Atrial Arrhythmia Recurrence After Ablation (NA)
• Assessment of the WATCHMAN™ Device in Patients Unsuitable for Oral Anticoagulation (NA)
• Effect of iNO in Patients With Submassive and Massive PE (PHASE2)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.