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The Chlorhexidine gluconate 0.05%
Chlorhexidine gluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing rapid bactericidal and bacteriostatic activity.
Chlorhexidine gluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing rapid bactericidal and bacteriostatic activity. Used for Oral rinse for plaque and gingivitis prevention, Topical antiseptic for wound care and skin disinfection, Oral hygiene in hospitalized or immunocompromised patients.
At a glance
| Generic name | The Chlorhexidine gluconate 0.05% |
|---|---|
| Also known as | Sterets unisept |
| Sponsor | HaEmek Medical Center, Israel |
| Drug class | Antimicrobial agent / Antiseptic |
| Modality | Small molecule |
| Therapeutic area | Infection Prevention / Oral Care |
| Phase | FDA-approved |
Mechanism of action
Chlorhexidine is a cationic biguanide that binds to negatively charged bacterial cell membranes, causing leakage of cellular contents and cell death. It also inhibits bacterial enzymes and denatures proteins. The 0.05% solution is commonly used as an oral rinse or topical antiseptic with activity against a wide range of gram-positive and gram-negative bacteria, as well as some fungi and viruses.
Approved indications
- Oral rinse for plaque and gingivitis prevention
- Topical antiseptic for wound care and skin disinfection
- Oral hygiene in hospitalized or immunocompromised patients
Common side effects
- Tooth staining (brown discoloration)
- Taste alteration
- Oral irritation or burning
- Increased calculus formation
- Allergic contact dermatitis (topical use)
Key clinical trials
- Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease (NA)
- Antiplaque Efficacy and Patient Reported Outcome of Chlorohexidine, Cetylpyridinium Chloride, and Essential Oil Mouthwashes in Orthodontic Patients (NA)
- Efficacy of Two Daily - Use CHX Based Mouth Rinses on Microbial Biofilm Accumulation, Gingivitis Development, and Staining (PHASE3)
- Effect of a Mouthwash Containing Chlorhexidine and Chlorine Dioxide on Halitosis (NA)
- Chlorhexidine Antiseptic Irrigation of the Bowel Segment During Radical Cystectomy and Urinary Diversion (NA)
- Clinical and Microbiological Comparison of 0.12% CHX and 0.05% CHX+0.05%CPC Mouthwashes in TPS Patients (NA)
- The Impact of Irrisept in Reducing Urinary Tract Infection During Urethral Catheter Removal. (NA)
- Sore Throat After Open Neck Elective Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- The Chlorhexidine gluconate 0.05% CI brief — competitive landscape report
- The Chlorhexidine gluconate 0.05% updates RSS · CI watch RSS
- HaEmek Medical Center, Israel portfolio CI