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Telbivudine, Lamivudine, Adefovir ,Enecavir

Shao-quan Zhang · FDA-approved active Small molecule

Telbivudine, Lamivudine, Adefovir ,Enecavir is a Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI) Small molecule drug developed by Shao-quan Zhang. It is currently FDA-approved for Chronic hepatitis B infection, Hepatitis B with compensated liver disease, Hepatitis B with decompensated cirrhosis (entecavir, adefovir). Also known as: no..

These nucleoside/nucleotide reverse transcriptase inhibitors block hepatitis B virus replication by inhibiting the viral reverse transcriptase enzyme.

These nucleoside/nucleotide reverse transcriptase inhibitors block hepatitis B virus replication by inhibiting the viral reverse transcriptase enzyme. Used for Chronic hepatitis B infection, Hepatitis B with compensated liver disease, Hepatitis B with decompensated cirrhosis (entecavir, adefovir).

At a glance

Generic nameTelbivudine, Lamivudine, Adefovir ,Enecavir
Also known asno.
SponsorShao-quan Zhang
Drug classNucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI)
TargetHepatitis B virus reverse transcriptase
ModalitySmall molecule
Therapeutic areaVirology/Hepatology
PhaseFDA-approved

Mechanism of action

Telbivudine, lamivudine, adefovir, and entecavir are antiviral agents that inhibit hepatitis B virus (HBV) reverse transcriptase, preventing viral DNA synthesis and replication. They are nucleoside or nucleotide analogues that get incorporated into the growing viral DNA chain, causing chain termination. These agents reduce HBV viral load and improve liver function in chronic hepatitis B patients.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about Telbivudine, Lamivudine, Adefovir ,Enecavir

What is Telbivudine, Lamivudine, Adefovir ,Enecavir?

Telbivudine, Lamivudine, Adefovir ,Enecavir is a Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI) drug developed by Shao-quan Zhang, indicated for Chronic hepatitis B infection, Hepatitis B with compensated liver disease, Hepatitis B with decompensated cirrhosis (entecavir, adefovir).

How does Telbivudine, Lamivudine, Adefovir ,Enecavir work?

These nucleoside/nucleotide reverse transcriptase inhibitors block hepatitis B virus replication by inhibiting the viral reverse transcriptase enzyme.

What is Telbivudine, Lamivudine, Adefovir ,Enecavir used for?

Telbivudine, Lamivudine, Adefovir ,Enecavir is indicated for Chronic hepatitis B infection, Hepatitis B with compensated liver disease, Hepatitis B with decompensated cirrhosis (entecavir, adefovir).

Who makes Telbivudine, Lamivudine, Adefovir ,Enecavir?

Telbivudine, Lamivudine, Adefovir ,Enecavir is developed and marketed by Shao-quan Zhang (see full Shao-quan Zhang pipeline at /company/shao-quan-zhang).

Is Telbivudine, Lamivudine, Adefovir ,Enecavir also known as anything else?

Telbivudine, Lamivudine, Adefovir ,Enecavir is also known as no..

What drug class is Telbivudine, Lamivudine, Adefovir ,Enecavir in?

Telbivudine, Lamivudine, Adefovir ,Enecavir belongs to the Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI) class. See all Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI) drugs at /class/nucleoside-nucleotide-reverse-transcriptase-inhibitor-nrti-ntrti.

What development phase is Telbivudine, Lamivudine, Adefovir ,Enecavir in?

Telbivudine, Lamivudine, Adefovir ,Enecavir is FDA-approved (marketed).

What are the side effects of Telbivudine, Lamivudine, Adefovir ,Enecavir?

Common side effects of Telbivudine, Lamivudine, Adefovir ,Enecavir include Lactic acidosis, Hepatic flare, Myopathy (telbivudine), Renal impairment (adefovir), Nausea, Fatigue.

What does Telbivudine, Lamivudine, Adefovir ,Enecavir target?

Telbivudine, Lamivudine, Adefovir ,Enecavir targets Hepatitis B virus reverse transcriptase and is a Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI).

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