Last reviewed 2026-04-23 · How we verify

Taurolidine Urokinase

Taurolidine urokinase works by combining the antimicrobial properties of taurolidine with the fibrinolytic properties of urokinase to treat infections and promote wound healing.

Taurolidine urokinase works by combining the antimicrobial properties of taurolidine with the fibrinolytic properties of urokinase to treat infections and promote wound healing. Used for Treatment of catheter-related bloodstream infections.

At a glance

Mechanism of action

Taurolidine has antimicrobial properties that help to reduce bacterial load, while urokinase has fibrinolytic properties that help to break down blood clots and promote wound healing. This combination makes taurolidine urokinase effective in treating infections and promoting wound healing.

Approved indications

• Treatment of catheter-related bloodstream infections

Common side effects

• Hypersensitivity reactions

Key clinical trials

• Prevention of Dialysis Catheter Malfunction With Prophylactic Use of a Taurolidine Containing Urokinase (PHASE3)
• Comparison of a TauroLock™ Based Regimen to 4% Citrate as Lock Solution in Tunneled Haemodialysis Catheters for the Prevention of Bacteraemia and Dysfunction (PHASE4)
• Management of Tunneled Catheter Thrombosis in Hemodialysis Patients: Prospective Study From Qatar (PHASE4)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Taurolidine Urokinase CI brief — competitive landscape report
• Taurolidine Urokinase updates RSS · CI watch RSS
• Universitair Ziekenhuis Brussel portfolio CI