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Systemic Therapy/Standard of Care
Systemic Therapy/Standard of Care is a PD-1 inhibitor Small molecule drug developed by Memorial Sloan Kettering Cancer Center. It is currently in Phase 3 development for Metastatic non-small cell lung cancer, PD-L1 positive, Metastatic melanoma, Head and neck squamous cell carcinoma.
This drug targets the PD-1 receptor to inhibit cancer cell growth.
This drug targets the PD-1 receptor to inhibit cancer cell growth. Used for Metastatic non-small cell lung cancer, PD-L1 positive, Metastatic melanoma, Head and neck squamous cell carcinoma.
At a glance
| Generic name | Systemic Therapy/Standard of Care |
|---|---|
| Sponsor | Memorial Sloan Kettering Cancer Center |
| Drug class | PD-1 inhibitor |
| Target | PD-1 |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
By binding to PD-1, the drug prevents cancer cells from evading the immune system, allowing the body's immune cells to attack and destroy the cancer cells. This leads to an anti-tumor response and potentially prolonged survival in patients with certain types of cancer.
Approved indications
- Metastatic non-small cell lung cancer, PD-L1 positive
- Metastatic melanoma
- Head and neck squamous cell carcinoma
Common side effects
- Pneumonitis
- Hypothyroidism
- Diarrhea
Key clinical trials
- Pre-Post Multimodal Assessment Of Severe Psoriasis Vulgaris Using Clinical, Dermoscopic And QoL Measures
- Local Ablative Therapy For Hormone Sensitive Oligometastatic Prostate Cancer (NA)
- Phase I Study of SYS6043 in Patients With Advanced/Metastatic Solid Tumors (PHASE1)
- HER2 Directed Dendritic Cell Vaccine During Neoadjuvant Therapy of HER2+Breast Cancer (EARLY_PHASE1)
- Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer (PHASE3)
- Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative (PHASE2, PHASE3)
- Phase Ib/II Trial of Envafolimab Plus Lenvatinib for Subjects With Solid Tumors (PHASE1, PHASE2)
- Prospective Evaluation of Targeted Axillary Dissection (TAD) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Systemic Therapy/Standard of Care CI brief — competitive landscape report
- Systemic Therapy/Standard of Care updates RSS · CI watch RSS
- Memorial Sloan Kettering Cancer Center portfolio CI
Frequently asked questions about Systemic Therapy/Standard of Care
What is Systemic Therapy/Standard of Care?
How does Systemic Therapy/Standard of Care work?
What is Systemic Therapy/Standard of Care used for?
Who makes Systemic Therapy/Standard of Care?
What drug class is Systemic Therapy/Standard of Care in?
What development phase is Systemic Therapy/Standard of Care in?
What are the side effects of Systemic Therapy/Standard of Care?
What does Systemic Therapy/Standard of Care target?
Related
- Drug class: All PD-1 inhibitor drugs
- Target: All drugs targeting PD-1
- Manufacturer: Memorial Sloan Kettering Cancer Center — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Metastatic non-small cell lung cancer, PD-L1 positive
- Indication: Drugs for Metastatic melanoma
- Indication: Drugs for Head and neck squamous cell carcinoma
- Compare: Systemic Therapy/Standard of Care vs similar drugs
- Pricing: Systemic Therapy/Standard of Care cost, discount & access