Last reviewed 2026-04-22 · How we verify

Synthomycine 5%

Synthomycin is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the bacterial ribosome.

Synthomycin is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the bacterial ribosome. Used for Topical bacterial infections (skin and soft tissue infections), Ophthalmic infections (as eye ointment formulation).

At a glance

Mechanism of action

Synthomycin (chloramphenicol) is a bacteriostatic antibiotic that works by inhibiting peptidyl transferase activity on the bacterial 70S ribosome, preventing peptide bond formation and halting protein synthesis. This mechanism is effective against a wide range of gram-positive and gram-negative bacteria, as well as some anaerobes and rickettsiae. The 5% formulation is typically used as a topical preparation for local antimicrobial effect.

Approved indications

• Topical bacterial infections (skin and soft tissue infections)
• Ophthalmic infections (as eye ointment formulation)

Common side effects

• Local irritation or contact dermatitis
• Allergic reactions
• Bone marrow suppression (with systemic use)

Key clinical trials

• The Efficacy of Permethrin 5%, Fusidic Acid 1% and Synthomycine 5% for Demodex - Blepharitis (PHASE4)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Synthomycine 5% CI brief — competitive landscape report
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• Barzilai Medical Center portfolio CI