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Nortriptyline is a tricyclic antidepressant that inhibits the reuptake of norepinephrine and serotonin at neuronal synapses, increasing their availability in the central nervous system.

Nortriptyline is a tricyclic antidepressant that inhibits the reuptake of norepinephrine and serotonin at neuronal synapses, increasing their availability in the central nervous system. Used for Major depressive disorder, Chronic pain conditions, Neuropathic pain.

At a glance

Mechanism of action

By blocking the reuptake transporters for norepinephrine and serotonin, nortriptyline increases the concentration of these neurotransmitters in the synaptic cleft, enhancing their signaling. This mechanism is thought to improve mood and alleviate symptoms of depression and certain pain conditions. Nortriptyline also has anticholinergic and antihistamine properties that contribute to its clinical effects.

Approved indications

• Major depressive disorder
• Chronic pain conditions
• Neuropathic pain
• Migraine prophylaxis

Common side effects

• Dry mouth
• Constipation
• Sedation
• Dizziness
• Orthostatic hypotension
• Weight gain
• Blurred vision
• Urinary retention

Key clinical trials

• RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT) (PHASE4)
• Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (PHASE4)

Primary sources

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