Last reviewed 2026-04-23 · How we verify

Sustained-release Metoprolol Succinate

Metoprolol succinate is a beta-blocker that works by blocking the effects of the hormone epinephrine, also known as adrenaline, and slowing the heart rate and reducing its workload.

Metoprolol succinate is a beta-blocker that works by blocking the effects of the hormone epinephrine, also known as adrenaline, and slowing the heart rate and reducing its workload. Used for Hypertension, Angina pectoris, Heart failure.

At a glance

Mechanism of action

By blocking the effects of epinephrine, metoprolol succinate reduces the heart rate and the force of contraction, which in turn reduces the heart's workload and oxygen demand. This can help to prevent angina and reduce the risk of heart attack and stroke.

Approved indications

• Hypertension
• Angina pectoris
• Heart failure
• Atrial fibrillation for rate control

Common side effects

• Dizziness
• Fatigue
• Headache
• Nausea
• Diarrhea

Key clinical trials

• A Clinical Study Using FAPI-PET Imaging to Assess the Postoperative Effects of TAVI in Patients With Aortic Stenosis (NA)
• Antihypertensive Drug Selection Based on Hemodynamic Phenotypes (PHASE4)
• Effect and Safety of Flecainide and Metoprolol Versus Metoprolol Alone to Suppress Ventricular Arrhythmias in Arrhythmic Mitral Valve Prolapse (PHASE3)
• Metoprolol and Trimetazidine for Coronary Heart Disease With Angina (NA)
• Low-dose Quadruple Combination Therapy in Patients With Hypertension (PHASE4)
• African American Study of Kidney Disease and Hypertension (PHASE3)
• Efficacy and Safety of Arotinolol Hydrochloride on Morning Blood Pressure and Heart Rate (PHASE4)
• Sympathetic Nervous System Modulation in Hypertension (PHASE4)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.