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Susceptibility-Guided Quadruple Therapy
Susceptibility-Guided Quadruple Therapy is a treatment approach that combines antibiotics to effectively target and eliminate Helicobacter pylori bacteria.
Susceptibility-Guided Quadruple Therapy is a treatment approach that combines antibiotics to effectively target and eliminate Helicobacter pylori bacteria. Used for Treatment of Helicobacter pylori infection.
At a glance
| Generic name | Susceptibility-Guided Quadruple Therapy |
|---|---|
| Sponsor | Sixth Affiliated Hospital, Sun Yat-sen University |
| Drug class | Antibiotic |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | Phase 3 |
Mechanism of action
This approach involves administering a combination of antibiotics to target the bacteria, which can cause stomach ulcers and other gastrointestinal issues. The susceptibility-guided aspect allows for the selection of antibiotics based on the specific antibiotic resistance patterns of the bacteria, increasing the likelihood of successful treatment.
Approved indications
- Treatment of Helicobacter pylori infection
Common side effects
- Gastrointestinal side effects
Key clinical trials
- Fecal Molecular Susceptibility-guided Hp First-line Therapy (PHASE4)
- Fecal Molecular Susceptibility-guided Hp Rescue Therapy (PHASE4)
- Efficacies of Susceptibility-guided vs Empiric Therapy for Rescue Treatment of Helicobacter Pylori Infection (PHASE4)
- Susceptibility Testing Guided Versus Empirical Therapy for Refractory H. Pylori Infection (PHASE4)
- Efficacy of Vonoprazan-based Rescue Therapy for H. Pylori Eradication (NA)
- Comparison of Keverprazan Hydrochloride-Amoxicillin Dual Therapy and Susceptibility-Guided Quadruple Therapy for Helicobacter Pylori Rescue Treatment (PHASE3)
- Tailored Vs. Empirical Helicobacter Pylori Infection Treatment (PHASE4)
- Efficacy of a 14-Day Bismuth-Containing Quadruple Therapy Guided by Drug Susceptibility Testing in Patients with Extremely Refractory Helicobacter Pylori Infection: an Exploratory Study
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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