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Sumatriptan and Naproxen sodium
Sumatriptan activates serotonin 5-HT1B/1D receptors to relieve migraine pain, while naproxen sodium inhibits cyclooxygenase enzymes to reduce inflammation and provide additional analgesic effect.
Sumatriptan activates serotonin 5-HT1B/1D receptors to relieve migraine pain, while naproxen sodium inhibits cyclooxygenase enzymes to reduce inflammation and provide additional analgesic effect. Used for Acute migraine with or without aura.
At a glance
| Generic name | Sumatriptan and Naproxen sodium |
|---|---|
| Sponsor | POZEN |
| Drug class | Triptan/NSAID combination |
| Target | 5-HT1B/1D receptors (sumatriptan); COX-1/COX-2 (naproxen sodium) |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | FDA-approved |
Mechanism of action
Sumatriptan is a selective serotonin receptor agonist that causes vasoconstriction of cranial blood vessels and inhibits neuropeptide release, addressing the vascular and neurogenic components of migraine. Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that blocks COX-1 and COX-2 enzymes, reducing prostaglandin synthesis and providing complementary pain relief and anti-inflammatory effects. The combination targets migraine through multiple mechanisms for enhanced efficacy.
Approved indications
- Acute migraine with or without aura
Common side effects
- Chest pain or tightness
- Dizziness
- Nausea
- Paresthesia
- Gastrointestinal upset
- Flushing
Key clinical trials
- i-NEED: NEw migrainE Drugs Database
- Use of the Combination of Sumatriptan and Naproxen in the Acute Treatment of Migraine: Real World Evidence Study
- Treatments of Migraine with Triptans in Individuals with Elevated Cardiovascular Risk and in Pregnant Women
- Study of Sumatriptan Naproxen Sodium Succinate Tablets for the Treatment of Acute Migraine Attacks (PHASE3)
- Treximet for Prevention of Post Traumatic Headache Associated With Cognitive Dysfunction (PHASE4)
- Trial of Comprehensive Migraine Intervention (PHASE4)
- Migraine Treatment in ED (NA)
- Comparing Naproxen to Sumatriptan for Emergency Headache Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sumatriptan and Naproxen sodium CI brief — competitive landscape report
- Sumatriptan and Naproxen sodium updates RSS · CI watch RSS
- POZEN portfolio CI