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Sulpiride use
Sulpiride is a dopamine antagonist that acts on D2 receptors in the brain.
Sulpiride is a dopamine antagonist that acts on D2 receptors in the brain. Used for Schizophrenia, Treatment-resistant schizophrenia.
At a glance
| Generic name | Sulpiride use |
|---|---|
| Also known as | Sulpirida |
| Sponsor | Hospital de Clinicas de Porto Alegre |
| Drug class | Dopamine antagonist |
| Target | D2 receptor |
| Modality | Small molecule |
| Therapeutic area | Psychiatry |
| Phase | Phase 3 |
Mechanism of action
It works by blocking the action of dopamine, a neurotransmitter involved in the regulation of movement and coordination. This leads to an increase in the activity of dopamine receptors, which helps to reduce symptoms of schizophrenia and other psychiatric disorders.
Approved indications
- Schizophrenia
- Treatment-resistant schizophrenia
Common side effects
- Drowsiness
- Dizziness
- Nausea
- Headache
- Parkinsonism
Key clinical trials
- Antipsychotic Induced Structural and Functional Brain Changes (PHASE4)
- Sulpiride Versus Placebo for Reducting Hot Flushes During Climacteric (PHASE3)
- Clinical Trial to Evaluate the Efficacy of Treatment vs Discontinuation in a First Episode of Non-affective Psychosis (PHASE3)
- Interpersonal Psychotherapy for Treatment Resistant Depression (NA)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |