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Sulfur Colloid
Technetium Tc 99m Sulfur Colloid is used for imaging by entering lymphatic capillaries, mixing with peritoneal fluid, or being taken up by the reticuloendothelial system.
Technetium Tc 99m Sulfur Colloid, marketed by the University of California, San Diego, is a radiopharmaceutical used primarily for lymph node localization in breast cancer or melanoma. Its key strength lies in its mechanism of action, which allows it to effectively enter lymphatic capillaries and be taken up by the reticuloendothelial system, enhancing diagnostic accuracy. The primary risk is the key composition patent expiry in 2028, which could lead to increased competition and potential revenue erosion.
At a glance
| Generic name | Sulfur Colloid |
|---|---|
| Also known as | 99mTc-SC, 99mTc-SC Sulfur Colloid |
| Sponsor | University of California, San Diego |
| Modality | Small molecule |
| Phase | FDA-approved |
Mechanism of action
When injected subcutaneously, Technetium Tc 99m Sulfur Colloid travels through lymphatic capillaries to lymph nodes, aiding in the detection of nodal metastasis. When injected intraperitoneally, it mixes with peritoneal fluid, and its clearance rate helps assess shunt patency. Intravenous injection allows imaging of reticuloendothelial system-rich structures.
Approved indications
- Lymph node localization in breast cancer or melanoma
- Evaluation of LeVeen shunt patency
- Imaging reticuloendothelial cells
- Esophageal transit and gastroesophageal reflux studies
Common side effects
Key clinical trials
- Lumason® Infusion vs. Bolus Administrations (PHASE3)
- Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy For Locally Advanced Breast Cancer (NA)
- CEUS Evaluation of Hydrocephalus in Neonates and Infants (PHASE2)
- Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue Abscesses (PHASE2)
- Use of Sentinel Lymph Node Biopsy in Patients With Early-Stage, Palpable Node-Positive HR+/HER2- Breast Cancer Having Upfront Surgery and Adjuvant Radiation
- Effects of Saccharomyces Boulardii CNCM I-745 on Antibiotic-Associated Perturbation in Children Treated for Acute Respiratory Infections (RESTORE Study) (PHASE4)
- CEUS for Blunt Abdominal Trauma in Children (PHASE4)
- Analysis of the Efficacy of Pressure Pad vs Pressure Bandage Immobilisation for Snake Bite First Aid in Healthy Volunteers. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |