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sugammadex 10 min after position change

Korea University Guro Hospital · FDA-approved active Small molecule

Sugammadex is a selective relaxant binding agent that encapsulates and inactivates rocuronium and vecuronium neuromuscular blocking agents, rapidly reversing neuromuscular blockade.

Sugammadex is a selective relaxant binding agent that encapsulates and inactivates rocuronium and vecuronium neuromuscular blocking agents, rapidly reversing neuromuscular blockade. Used for Reversal of neuromuscular blockade induced by rocuronium or vecuronium in adults undergoing surgery.

At a glance

Generic namesugammadex 10 min after position change
Also known asrestricted dose of rocuronium
SponsorKorea University Guro Hospital
Drug classSelective relaxant binding agent
TargetRocuronium and vecuronium (neuromuscular blocking agents)
ModalitySmall molecule
Therapeutic areaAnesthesia/Perioperative Medicine
PhaseFDA-approved

Mechanism of action

Sugammadex forms a tight 1:1 complex with steroidal neuromuscular blocking agents (rocuronium and vecuronium) through host-guest chemistry, effectively removing them from the neuromuscular junction and plasma. This allows acetylcholine to restore normal neuromuscular transmission without requiring acetylcholinesterase inhibitors. The timing notation '10 min after position change' appears to refer to a specific clinical protocol for administration timing post-operatively.

Approved indications

Common side effects

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