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Sufentanil injection
Sufentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation.
Sufentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation. Used for Perioperative analgesia and sedation during anesthesia, Acute postoperative pain management.
At a glance
| Generic name | Sufentanil injection |
|---|---|
| Also known as | sufentanil, Sufenta®, Johnson&Johnson, USA, 108/26, 15.08.2000, adenotonsillectomy |
| Sponsor | Eye & ENT Hospital of Fudan University |
| Drug class | Opioid agonist |
| Target | Mu (μ) opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Sufentanil activates mu opioid receptors, which are G-protein coupled receptors distributed throughout the brain and spinal cord. This activation inhibits the transmission of pain signals and produces profound analgesia, sedation, and respiratory depression. It is approximately 5-10 times more potent than fentanyl and is used primarily for perioperative anesthesia and analgesia.
Approved indications
- Perioperative analgesia and sedation during anesthesia
- Acute postoperative pain management
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Dizziness
- Chest wall rigidity
Key clinical trials
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Rhomboid Intercostal Nerve Block in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery (NA)
- Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section (PHASE4)
- Tubeless Spontaneous Ventilation Anesthesia in Kidney Transplantation (NA)
- Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery (PHASE4)
- Effects and Safety of Oliceridine in Anesthesia Induction:A Randomised Controlled Trial (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |