Last reviewed 2026-04-23 · How we verify

Structured Treatment Interruptions

Structured Treatment Interruptions involve temporarily stopping antiretroviral therapy to assess the body's natural ability to control HIV.

Structured Treatment Interruptions involve temporarily stopping antiretroviral therapy to assess the body's natural ability to control HIV. Used for HIV-1 infection.

At a glance

Mechanism of action

This approach allows researchers to evaluate the effectiveness of the immune system in suppressing the virus, providing valuable insights into the disease's progression and the potential for long-term remission. By temporarily interrupting treatment, the body's natural defenses can be observed, and the impact of antiretroviral therapy on the immune system can be better understood.

Approved indications

• HIV-1 infection

Common side effects

• Immune reconstitution inflammatory syndrome
• Resurgence of HIV-1
• Other opportunistic infections

Key clinical trials

• Effects of Immunization With HIV-1 Immunogen Plus Anti-HIV Treatment Interruption on the Levels of HIV (PHASE2)
• CSP #512 - Options in Management With Anti-Retrovirals (NA)
• Anti-HIV Treatment Interruptions in HIV Infected Adults in South Africa (NA)
• Anti-HIV Medications and Structured Treatment Interruptions for People Recently Infected With HIV (NA)
• Early and Intermittent Antiretroviral Therapy in Naive HIV Infected Adults (PHASE2)
• Structured Treatment Interruption (STI) in Acute/Primary HIV (NA)
• A Study of Health-Related Quality of Life in HIV-Infected Patients Undergoing Structured Treatment Interruptions of Highly Active Antiretroviral Therapy
• BASTA Study on STI in HIV Infected Patients (PHASE3)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.