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Steroid - Triamcinolone Acetonide
Triamcinolone acetonide is a synthetic corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors.
Triamcinolone acetonide is a synthetic corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors. Used for Inflammatory and allergic skin conditions (dermatitis, psoriasis, lichen planus), Rheumatoid arthritis and other inflammatory joint diseases, Allergic rhinitis.
At a glance
| Generic name | Steroid - Triamcinolone Acetonide |
|---|---|
| Also known as | Kenalog-40 |
| Sponsor | University of Missouri-Columbia |
| Drug class | Corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Immunology, Dermatology, Rheumatology |
| Phase | FDA-approved |
Mechanism of action
Triamcinolone acetonide is a medium-to-high potency glucocorticoid that works by binding to intracellular glucocorticoid receptors, leading to suppression of pro-inflammatory cytokine production, inhibition of immune cell activation and migration, and reduction of inflammatory mediator release. It is used topically, intramuscularly, intra-articularly, and systemically depending on the indication.
Approved indications
- Inflammatory and allergic skin conditions (dermatitis, psoriasis, lichen planus)
- Rheumatoid arthritis and other inflammatory joint diseases
- Allergic rhinitis
- Asthma
- Adrenocortical insufficiency
- Ocular inflammation
Common side effects
- Skin atrophy (with topical use)
- Hypothalamic-pituitary-adrenal (HPA) axis suppression
- Hyperglycemia
- Immunosuppression and increased infection risk
- Osteoporosis (with chronic systemic use)
- Mood changes, insomnia
- Hypertension
Key clinical trials
- Dose Dependent Steroid Injections (PHASE4)
- Sialendoscopy Versus Photobiomodulation in Prevention of Radiation Induced Xerostomia (NA)
- Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone (PHASE4)
- Local Methotrexate Injections for the Treatment of Nail Psoriasis (PHASE4)
- Bladder Directed vs. Pelvic Floor Therapy in IC/BPS (PHASE2)
- Steroid Treatment for Elimination of Rebound Obstruction From Intranasal Decongestants (PHASE2)
- Corticosteroid Meniscectomy Randomized Trial (PHASE4)
- Triamcinolone Acetonide Injection for Upper Eyelid Retraction in Thyroid Eye Disease (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |