Last reviewed · How we verify
Sterile Sodium Chloride
Sterile sodium chloride is an isotonic saline solution that restores and maintains electrolyte balance and fluid volume in the body.
Sterile sodium chloride is an isotonic saline solution that restores and maintains electrolyte balance and fluid volume in the body. Used for Fluid and electrolyte replacement in dehydration, Maintenance of fluid and electrolyte balance during surgery or critical illness, Vehicle for intravenous medication administration.
At a glance
| Generic name | Sterile Sodium Chloride |
|---|---|
| Also known as | 0.9% Sodium Chloride Water for Injection |
| Sponsor | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
| Drug class | Electrolyte replacement / Crystalloid fluid |
| Modality | Small molecule |
| Therapeutic area | General medicine / Supportive care |
| Phase | FDA-approved |
Mechanism of action
Sodium chloride is an essential electrolyte that regulates osmotic pressure, maintains cellular hydration, and supports nerve and muscle function. As a sterile injectable solution, it is used to replace lost fluids and electrolytes, restore blood volume, and serve as a vehicle for administering other medications. It works by providing physiologically balanced concentrations of sodium and chloride ions.
Approved indications
- Fluid and electrolyte replacement in dehydration
- Maintenance of fluid and electrolyte balance during surgery or critical illness
- Vehicle for intravenous medication administration
Common side effects
- Hypernatremia (elevated sodium levels)
- Fluid overload / pulmonary edema
- Phlebitis at injection site
- Hypokalemia (low potassium)
Key clinical trials
- PRP Injection Into the Sacroiliac Joint After Ipsilateral THA: Effects on Early Recovery and Function (SIJ-THA Randomized Trial) (NA)
- Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection (PHASE2)
- Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1) (PHASE1)
- A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE) (PHASE3)
- A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade (PHASE2)
- Pilot Study of IC14 (Atibuclimab), an Anti-CD14 Monoclonal Antibody, to Treat STEMI (PHASE1, PHASE2)
- Tocilizumab in Lung Transplantation (PHASE2)
- Subconjunctival Humira for Boston Keratoprosthesis (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: