Last reviewed · How we verify
Standard Oral Vasodilators
Oral vasodilators relax blood vessel smooth muscle to widen blood vessels and reduce blood pressure.
Oral vasodilators relax blood vessel smooth muscle to widen blood vessels and reduce blood pressure. Used for Hypertension, Angina pectoris, Heart failure.
At a glance
| Generic name | Standard Oral Vasodilators |
|---|---|
| Also known as | Usual Care |
| Sponsor | The Cleveland Clinic |
| Drug class | Vasodilator |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
These drugs work by various mechanisms (such as calcium channel blockade, nitrate donation, or phosphodiesterase inhibition) to cause vasodilation—relaxation of the smooth muscle in blood vessel walls. This widening of blood vessels decreases peripheral vascular resistance and reduces blood pressure, improving blood flow to tissues and reducing cardiac workload.
Approved indications
- Hypertension
- Angina pectoris
- Heart failure
- Peripheral vascular disease
Common side effects
- Headache
- Dizziness
- Flushing
- Tachycardia
- Edema
Key clinical trials
- B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure Pilot Trial (PHASE2)
- Nitrous Oxide for Pain Management During IUD Insertion in Nulliparous Adolescent Women (PHASE2, PHASE3)
- Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease (PHASE4)
- Treatment of PH With Angiotensin II Receptor Blocker and Neprilysin Inhibitor in HFpEF Patients With CardioMEMS Device (PHASE3)
- Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study (PHASE4)
- Comparison of ARNI to Alternate Oral Vasodilator Therapies in Patients With Low Cardiac Output (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Standard Oral Vasodilators CI brief — competitive landscape report
- Standard Oral Vasodilators updates RSS · CI watch RSS
- The Cleveland Clinic portfolio CI