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Standard of care neoadjuvant therapy
Standard of care neoadjuvant therapy is a Small molecule drug developed by Galvanize Therapeutics, Inc.. It is currently FDA-approved for Various solid tumors as neoadjuvant pre-operative therapy (specific indication depends on cancer type and institutional standard of care). Also known as: Carboplatinum, Cipsplatin, Pemetrexed, Gemcitabine.
Standard of care neoadjuvant therapy refers to established pre-operative treatment regimens designed to shrink tumors before surgical resection.
Standard of care neoadjuvant therapy refers to established pre-operative treatment regimens designed to shrink tumors before surgical resection. Used for Various solid tumors as neoadjuvant pre-operative therapy (specific indication depends on cancer type and institutional standard of care).
At a glance
| Generic name | Standard of care neoadjuvant therapy |
|---|---|
| Also known as | Carboplatinum, Cipsplatin, Pemetrexed, Gemcitabine, Paclitaxel |
| Sponsor | Galvanize Therapeutics, Inc. |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | FDA-approved |
Mechanism of action
Neoadjuvant therapy typically involves chemotherapy, targeted therapy, immunotherapy, or combinations thereof administered before primary surgical treatment. The goal is to reduce tumor burden, improve surgical outcomes, and potentially increase the likelihood of complete resection. The specific mechanism depends on the underlying drug class and cancer type being treated.
Approved indications
- Various solid tumors as neoadjuvant pre-operative therapy (specific indication depends on cancer type and institutional standard of care)
Common side effects
- Chemotherapy-related toxicity (varies by regimen)
- Hematologic toxicity
- Gastrointestinal toxicity
- Cardiac toxicity (if anthracycline-based)
Key clinical trials
- Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer (PHASE2)
- A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss (PHASE2)
- Neoadjuvant Ficerafusp Alfa With Pembrolizumab in Resectable SCC (PHASE2)
- A Study of (Neo)Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Cutaneous Squamous Cell Carcinoma (V940-007) (PHASE2, PHASE3)
- Prospective Validation of Ataraxis AI Test for Predicting Treatment Response in Neoadjuvant Breast Cancer
- HER2 Directed Dendritic Cell Vaccine During Neoadjuvant Therapy of HER2+Breast Cancer (EARLY_PHASE1)
- Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer (PHASE2)
- Testing MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Standard of care neoadjuvant therapy CI brief — competitive landscape report
- Standard of care neoadjuvant therapy updates RSS · CI watch RSS
- Galvanize Therapeutics, Inc. portfolio CI
Frequently asked questions about Standard of care neoadjuvant therapy
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Related
- Manufacturer: Galvanize Therapeutics, Inc. — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Various solid tumors as neoadjuvant pre-operative therapy (specific indication depends on cancer type and institutional standard of care)
- Also known as: Carboplatinum, Cipsplatin, Pemetrexed, Gemcitabine, Paclitaxel
- Compare: Standard of care neoadjuvant therapy vs similar drugs
- Pricing: Standard of care neoadjuvant therapy cost, discount & access