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Standard dose PTCY
PTCY is a small molecule that targets the P2Y12 receptor.
PTCY is a small molecule that targets the P2Y12 receptor. Used for Acute coronary syndrome, Myocardial infarction.
At a glance
| Generic name | Standard dose PTCY |
|---|---|
| Sponsor | Shanghai Jiao Tong University School of Medicine |
| Drug class | P2Y12 inhibitor |
| Target | P2Y12 receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
PTCY works by selectively inhibiting the P2Y12 receptor, which is involved in platelet activation and aggregation. This leads to a reduction in platelet aggregation and subsequent thrombus formation.
Approved indications
- Acute coronary syndrome
- Myocardial infarction
Common side effects
- Bleeding
- Thrombocytopenia
- Cerebrovascular accident
Key clinical trials
- Fludarabine and Intermediate-dose TBI Followed by PTCy in Patients Undergoing Allo Transplant for Heme Malignancies (PHASE2)
- The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation (PHASE1, PHASE2)
- Study Comparing Reduced Versus Standard Dose Post-transplantation Cyclophosphamide in Combination With Post-engraftment Anti-thymoglobin as Graft Versus Host Disease Prophylaxis in Alternative Donor Peripheral Stem Cell Transplantation (PHASE3)
- A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation (PHASE2)
- A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT) (PHASE2)
- A Study of Ruxolitinib for Preventing Graft-Versus-Host Disease in People With a Hematologic Malignancy Who Will Receive a Stem Cell Transplant (PHASE2)
- Optimizing PTCy Dose and Timing (PHASE1, PHASE2)
- Optimizing GVHD Prophylaxis After Allogeneic Hematopoietic Cell Transplantation (PHASE2)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |