Last reviewed 2026-05-28 · How we verify

Standard Dose Ibuprofen

Standard Dose Ibuprofen is a Nonsteroidal anti-inflammatory drug (NSAID) Small molecule drug developed by Ottawa Hospital Research Institute. It is currently FDA-approved for Mild to moderate pain, Fever reduction, Inflammation associated with arthritis and musculoskeletal conditions.

Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing inflammation, pain, and fever.

Standard dose ibuprofen is a small molecule that inhibits the enzyme cyclooxygenase, which is involved in the production of prostaglandins. It is used to manage conditions such as acute post-operative pain, post-operative pain, and possibly other conditions including obesity and post-bariatric surgery pain, as indicated by clinical trials.

At a glance

Mechanism of action

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that non-selectively blocks COX-1 and COX-2 enzymes, which are responsible for synthesizing prostaglandins—key mediators of inflammation, pain, and fever. By reducing prostaglandin levels in affected tissues, ibuprofen provides analgesic, anti-inflammatory, and antipyretic effects. It is widely used for mild to moderate pain and inflammatory conditions.

Approved indications

• Mild to moderate pain
• Fever reduction
• Inflammation associated with arthritis and musculoskeletal conditions

Common side effects

• Gastrointestinal upset (nausea, dyspepsia, abdominal pain)
• Headache
• Dizziness
• Rash
• Gastrointestinal bleeding (with chronic use)
• Cardiovascular events (with chronic use)

Key clinical trials

• ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
• Musculoskeletal Outcomes Using Tylenol/Ibuprofen vs. Oral Steroids in New Injuries (PHASE4)
• Comparison of M-TAPA and TAP Blocks on Postoperative Analgesia in Laparoscopic Inguinal Hernia Surgeries (NA)
• Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients (NA)
• Psychosocial Factors and Postoperative Pain in Aesthetic Breast Surgery
• The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair (PHASE4)
• Ultrasound-Guided Regional Blocks for Postoperative Analgesia After Laparoscopic Cholecystectomy (NA)
• Reduced Opioid Prescription After Laparoscopic Hysterectomy (NA)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Standard Dose Ibuprofen CI brief — competitive landscape report
• Standard Dose Ibuprofen updates RSS · CI watch RSS
• Ottawa Hospital Research Institute portfolio CI

Frequently asked questions about Standard Dose Ibuprofen

Related

• Drug class: All Nonsteroidal anti-inflammatory drug (NSAID) drugs
• Target: All drugs targeting COX-1, COX-2
• Manufacturer: Ottawa Hospital Research Institute — full pipeline
• Therapeutic area: All drugs in Pain Management, Inflammation
• Indication: Drugs for Mild to moderate pain
• Indication: Drugs for Fever reduction
• Indication: Drugs for Inflammation associated with arthritis and musculoskeletal conditions

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing