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Stabilized chlorine dioxide oral rinse
Stabilized chlorine dioxide acts as an antimicrobial and oxidizing agent that disrupts bacterial cell membranes and inactivates microorganisms in the oral cavity.
Stabilized chlorine dioxide acts as an antimicrobial and oxidizing agent that disrupts bacterial cell membranes and inactivates microorganisms in the oral cavity. Used for Oral antimicrobial rinse for oral hygiene and plaque reduction, Oral wound irrigation and antimicrobial treatment.
At a glance
| Generic name | Stabilized chlorine dioxide oral rinse |
|---|---|
| Sponsor | Rowpar Pharmaceuticals, Inc. |
| Drug class | Antimicrobial oral rinse |
| Modality | Small molecule |
| Therapeutic area | Oral Health / Dentistry |
| Phase | FDA-approved |
Mechanism of action
Chlorine dioxide is a potent oxidizing agent that penetrates microbial cell walls and disrupts cellular function through oxidative damage to proteins, lipids, and nucleic acids. When stabilized for oral use, it provides broad-spectrum antimicrobial activity against bacteria, fungi, and some viruses in the mouth. This mechanism makes it useful for oral hygiene and antimicrobial rinse applications.
Approved indications
- Oral antimicrobial rinse for oral hygiene and plaque reduction
- Oral wound irrigation and antimicrobial treatment
Common side effects
- Oral irritation or burning sensation
- Tooth staining
- Taste alteration
Key clinical trials
- Antiseptic Mouthwash / Pre-Procedural Rinse on SARS-CoV-2 Load (COVID-19) (PHASE2)
- The Efficacy of Stabilized Chlorine Dioxide Rinse as a Chemical Adjuvant for Treatment of Per-implant Mucositis (PHASE4)
- Controlling Oral Malodor by ClōSYS® Oral Rinse (NA)
- Controlling Oral Malodor by ClōSYS Oral Rinse (NA)
- Bad Breath Response to Tongue Scraper and Rinses (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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