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SSG and Paromomycin sulphate
SSG and Paromomycin sulphate is a Amino-guanidine and aminoglycoside antibiotic Small molecule drug developed by Drugs for Neglected Diseases. It is currently in Phase 3 development for Treatment of visceral leishmaniasis.
SSG and Paromomycin sulphate work by inhibiting protein synthesis in the parasite.
SSG and Paromomycin sulphate work by inhibiting protein synthesis in the parasite. Used for Treatment of visceral leishmaniasis.
At a glance
| Generic name | SSG and Paromomycin sulphate |
|---|---|
| Sponsor | Drugs for Neglected Diseases |
| Drug class | Amino-guanidine and aminoglycoside antibiotic |
| Target | Ribosome |
| Modality | Small molecule |
| Therapeutic area | Infectious Diseases |
| Phase | Phase 3 |
Mechanism of action
SSG and Paromomycin sulphate are a combination of an amino-guanidine and an aminoglycoside antibiotic, respectively. They inhibit protein synthesis in the parasite by binding to the ribosome, ultimately leading to the death of the parasite.
Approved indications
- Treatment of visceral leishmaniasis
Common side effects
- Nausea
- Vomiting
- Diarrhea
Key clinical trials
- LXE408 for Treatment of Visceral Leishmaniasis in Ethiopia, a Proof of Concept Study (PHASE2)
- A Study to Assess Immune Response Status in Patients Before and After Treatment for Visceral Leishmaniasis
- Miltefosine/Paromomycin Phase III Trial for Treatment of Primary Visceral Leishmaniasis (VL) Patients in Eastern Africa (PHASE3)
- Efficacy/Safety of Sodium Stibogluconate (SSG) Versus Paromomycin (PM) and SSG/PM Combination to Treat V Leishmaniasis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- SSG and Paromomycin sulphate CI brief — competitive landscape report
- SSG and Paromomycin sulphate updates RSS · CI watch RSS
- Drugs for Neglected Diseases portfolio CI
Frequently asked questions about SSG and Paromomycin sulphate
What is SSG and Paromomycin sulphate?
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Related
- Drug class: All Amino-guanidine and aminoglycoside antibiotic drugs
- Target: All drugs targeting Ribosome
- Manufacturer: Drugs for Neglected Diseases — full pipeline
- Therapeutic area: All drugs in Infectious Diseases
- Indication: Drugs for Treatment of visceral leishmaniasis
- Compare: SSG and Paromomycin sulphate vs similar drugs
- Pricing: SSG and Paromomycin sulphate cost, discount & access