Last reviewed · How we verify
Split thickness skin graft
Split thickness skin graft is a Biologic drug developed by CellTherX. It is currently FDA-approved for Acute and chronic wound coverage, Burn injuries, Traumatic wounds.
A split thickness skin graft is a surgical tissue transplant that replaces damaged or missing skin by transferring a partial-thickness layer of healthy skin from a donor site to the wound area.
A split thickness skin graft is a type of graft surgery that involves transplanting skin without a defined circulation. It is used to treat various conditions, including skin graft detachment, infection, surgical site pain, burns, and postoperative pain, among others.
At a glance
| Generic name | Split thickness skin graft |
|---|---|
| Sponsor | CellTherX |
| Modality | Biologic |
| Therapeutic area | Wound Care / Dermatology / Regenerative Medicine |
| Phase | FDA-approved |
Mechanism of action
The graft consists of the epidermis and a portion of the dermis, which are harvested from a donor site (typically the patient's own body) and placed over the wound bed. The graft re-establishes skin barrier function, reduces infection risk, and promotes healing through neovascularization and integration with the underlying tissue. This is a surgical/regenerative approach rather than a pharmacological mechanism.
Approved indications
- Acute and chronic wound coverage
- Burn injuries
- Traumatic wounds
- Surgical defects
- Diabetic ulcers
Common side effects
- Graft failure or poor take
- Infection at graft or donor site
- Scarring and contracture
- Donor site pain and delayed healing
- Hypertrophic scarring
Key clinical trials
- Comparing Chitosan Sponge With Hydrocolloid as Dressing for Split-thickness Skin Graft Donor Site Wounds (NA)
- Multicenter Single-arm Trial to Investigate Clinical Outcomes When Cohealyx™ is Used for Full Thickness Wounds (NA)
- Resurfacing of Foot and Distal Leg Soft Tissue Defects Using Reversed Pedicled Peroneal Artery Flaps Augmented by Superficial Sural Artery (NA)
- Skin Color Matching in Head and Neck Reconstructive Surgery (NA)
- Cellular Reprogramming-Enhanced Skin Grafting for Diabetic Foot Ulcers (NA)
- Tumescence in HNC Skin Graft Reconstruction (PHASE3)
- Autologous Fat Grafting Beneath Penile Split Thickness Skin Graft Placement During Penile Reconstruction (NA)
- Factors Affecting Split Thickness Skin Graft Success Rates in Patients Who Underwent a Radial Forearm or Fibula Free Flap (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Split thickness skin graft CI brief — competitive landscape report
- Split thickness skin graft updates RSS · CI watch RSS
- CellTherX portfolio CI
Frequently asked questions about Split thickness skin graft
What is Split thickness skin graft?
How does Split thickness skin graft work?
What is Split thickness skin graft used for?
Who makes Split thickness skin graft?
What development phase is Split thickness skin graft in?
What are the side effects of Split thickness skin graft?
Related
- Manufacturer: CellTherX — full pipeline
- Therapeutic area: All drugs in Wound Care / Dermatology / Regenerative Medicine
- Indication: Drugs for Acute and chronic wound coverage
- Indication: Drugs for Burn injuries
- Indication: Drugs for Traumatic wounds
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing