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Split-dose low-volume PEG
Split-dose low-volume polyethylene glycol (PEG) solution reduces bowel preparation volume while maintaining efficacy by dividing the dose into smaller administrations.
Split-dose low-volume polyethylene glycol (PEG) solution reduces bowel preparation volume while maintaining efficacy by dividing the dose into smaller administrations. Used for Bowel preparation prior to colonoscopy.
At a glance
| Generic name | Split-dose low-volume PEG |
|---|---|
| Sponsor | Kyunghee University Medical Center |
| Drug class | Osmotic laxative / bowel preparation agent |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
This formulation uses polyethylene glycol as an osmotic laxative agent in a lower total volume compared to standard PEG preparations, administered in split doses (typically evening before and morning of procedure) to improve tolerability and patient compliance. The split-dosing strategy allows for better absorption and efficacy while reducing the gastrointestinal burden of consuming large fluid volumes in a single sitting.
Approved indications
- Bowel preparation prior to colonoscopy
Common side effects
- Nausea
- Abdominal bloating
- Abdominal cramping
- Vomiting
Key clinical trials
- Cleansing Options in Out-Patient Setting to Improve Tolerance (COOP SIT) Trial (PHASE4)
- PEG-Asc Vs. SPMC for Bowel Preparation in Capsule-based Procedures (NA)
- Efficacy And Tolerability Of Asymmetric Split Regimen For Bowel Preparation (NA)
- Can Artificial Intelligence Reduce Consumption of Standard High Volume Bowel Preparation Regimen Among Older Population, Without Compromising the Quality of Colonoscopy? An International Multi-centre Randomized Controlled Trial. (NA)
- Effect of Low-volume (1L) vs Intermediate-volume (2L) Bowel Preparation on Cost-effectiveness and Quality of Life (NA)
- Two Low Volume Regimens for Colorectal Cancer Screening Colonoscopy (PHASE4)
- Polyethylene Glycol Versus Low Volume Solutions Prior to Colonoscopy (PHASE4)
- Impact of a Predictive Score of Bowel Preparation Quality in Clinical Practice (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Split-dose low-volume PEG CI brief — competitive landscape report
- Split-dose low-volume PEG updates RSS · CI watch RSS
- Kyunghee University Medical Center portfolio CI