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Spironolactone + Dexamethasone
Spironolactone is a potassium-sparing diuretic that acts as an aldosterone antagonist, while dexamethasone is a synthetic glucocorticoid that exerts anti-inflammatory and immunosuppressive effects.
Spironolactone is a potassium-sparing diuretic that acts as an aldosterone antagonist, while dexamethasone is a synthetic glucocorticoid that exerts anti-inflammatory and immunosuppressive effects. Used for Hypertension, Heart failure.
At a glance
| Generic name | Spironolactone + Dexamethasone |
|---|---|
| Sponsor | Chita State Regional Clinical Hospital Number 1 |
| Drug class | Potassium-sparing diuretic, Glucocorticoid |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular, Endocrinology |
| Phase | Phase 3 |
Mechanism of action
Spironolactone works by blocking the action of aldosterone, a hormone that promotes sodium retention and potassium excretion in the kidneys. Dexamethasone, on the other hand, is a potent anti-inflammatory agent that suppresses the immune system by inhibiting the production of pro-inflammatory cytokines.
Approved indications
- Hypertension, Heart failure
Common side effects
- Hyperkalemia
- Edema
- Nausea
- Vomiting
- Hypertension
- Edema
- Gynecomastia
- Hirsutism
- Acne
- Insomnia
Key clinical trials
- Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
- Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men (PHASE2)
- Effect of Spironolactone on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess (NA)
- Spironolactone and Dexamethasone in Patients Hospitalized With COVID-19 (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |