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Spinal analgesia
Spinal analgesia is a Small molecule drug developed by McGill University Health Centre/Research Institute of the McGill University Health Centre. It is currently FDA-approved for Acute postoperative pain, Chronic pain conditions, Cancer pain. Also known as: Spinal block, intrathecal block, Analgesia cocktail.
Spinal analgesia delivers pain-relieving medications directly into the cerebrospinal fluid around the spinal cord to block pain signals at their source.
Spinal analgesia is a form of regional anesthesia involving the injection of a local anesthetic into the subarachnoid space. It is typically administered through a fine needle as a single-shot dose, although continuous spinal anesthesia can also be achieved through an intrathecal catheter.
At a glance
| Generic name | Spinal analgesia |
|---|---|
| Also known as | Spinal block, intrathecal block, Analgesia cocktail |
| Sponsor | McGill University Health Centre/Research Institute of the McGill University Health Centre |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
This is an administration route and technique rather than a specific drug entity. Spinal analgesia involves injecting analgesic agents (such as local anesthetics, opioids, or other pain medications) into the intrathecal space surrounding the spinal cord. By delivering medications directly to the central nervous system at the spinal level, it achieves potent pain relief with lower systemic doses, reducing side effects compared to systemic administration.
Approved indications
- Acute postoperative pain
- Chronic pain conditions
- Cancer pain
- Labor pain
Common side effects
- Headache (post-dural puncture)
- Hypotension
- Urinary retention
- Pruritus
- Nausea
Key clinical trials
- Inflammatory Markers in Lumbar Radicular Pain Treated With PRF and TFESI
- Prospective Evaluation of Intrathecal Targeted Drug Delivery for Cancer Associated Pain
- Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion (EARLY_PHASE1)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (NA)
- Comparison Between Dexamethasone and Dexmedetomidine in Spinal Anesthesia for Cases With Fracture Pelvis Fixation (EARLY_PHASE1)
- Analgesic Techniques for Robotic Prostatectomy Procedures (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Spinal analgesia CI brief — competitive landscape report
- Spinal analgesia updates RSS · CI watch RSS
- McGill University Health Centre/Research Institute of the McGill University Health Centre portfolio CI
Frequently asked questions about Spinal analgesia
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Related
- Manufacturer: McGill University Health Centre/Research Institute of the McGill University Health Centre — full pipeline
- Therapeutic area: All drugs in Pain Management
- Indication: Drugs for Acute postoperative pain
- Indication: Drugs for Chronic pain conditions
- Indication: Drugs for Cancer pain
- Also known as: Spinal block, intrathecal block, Analgesia cocktail
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing