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SPECT MPI
SPECT MPI is a diagnostic imaging agent that uses technetium-99m labeled tracers to visualize myocardial perfusion and detect areas of reduced blood flow in the heart.
SPECT MPI is a diagnostic imaging agent that uses technetium-99m labeled tracers to visualize myocardial perfusion and detect areas of reduced blood flow in the heart. Used for Detection of coronary artery disease and myocardial ischemia, Assessment of myocardial viability post-infarction, Risk stratification in patients with known or suspected coronary artery disease.
At a glance
| Generic name | SPECT MPI |
|---|---|
| Sponsor | GE Healthcare |
| Drug class | Diagnostic radiopharmaceutical |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
SPECT (Single Photon Emission Computed Tomography) MPI (Myocardial Perfusion Imaging) employs gamma-emitting radiopharmaceuticals that accumulate in viable myocardial tissue proportional to regional blood flow. The imaging allows detection of ischemia, infarction, and viability assessment by comparing perfusion patterns at rest and during stress (exercise or pharmacologic).
Approved indications
- Detection of coronary artery disease and myocardial ischemia
- Assessment of myocardial viability post-infarction
- Risk stratification in patients with known or suspected coronary artery disease
Common side effects
- Radiation exposure
- Stress-induced adverse events (with pharmacologic stress agents)
- Injection site reactions
Key clinical trials
- Hyperpolarized 13C Pyruvate-MRI and FDG-PET in a Single Exam for the Prognosis of Ischemic Cardiomyopathy
- Comparative Imaging of XTR004 PET and MIBI SPECT in Borderline Coronary Stenosis (PHASE2)
- Myocardial Perfusion Imaging Galmydar Rest/Stress (EARLY_PHASE1)
- Amyloidosis TTR Flow Reserve Evaluation (NA)
- Mechanical Dyssynchrony and Microvascular Dysfunction by SPECT
- Image Fusion of SPECT MPI and Fluoroscopy Venography to Guide LV Lead Placement for Improved CRT Response (GUIDE-CRT II) (NA)
- Myocardial Perfusion Quantification With SPECT Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary CTA (NA)
- Multi-Center Evaluation of Feasibility of SPECT Measurement of Myocardial Blood Flow and Reserve
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- SPECT MPI CI brief — competitive landscape report
- SPECT MPI updates RSS · CI watch RSS
- GE Healthcare portfolio CI