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sodium zirconium cyclic silicate

Peking University First Hospital · FDA-approved active Small molecule

Sodium zirconium cyclic silicate is a non-absorbed potassium binder that traps potassium in the gastrointestinal tract through ion exchange, reducing serum potassium levels.

Sodium zirconium cyclic silicate is a potassium binder under investigation for managing hyperkalemia. It has shown promise in early clinical trials but lacks FDA approval. The drug is being studied for its impact on cardiac electrical stability and as an adjunct in pulpotomy techniques.

At a glance

Generic namesodium zirconium cyclic silicate
Also known ashemodialysis
SponsorPeking University First Hospital
Drug classPotassium binder
TargetPotassium ion (K+) in gastrointestinal lumen
ModalitySmall molecule
Therapeutic areaNephrology / Cardiology
PhaseFDA-approved

Mechanism of action

The drug is a microporous, inorganic compound that selectively binds potassium ions in the colon via a non-selective cation exchange mechanism. It does not require acidic conditions to function and works throughout the entire gastrointestinal tract. The potassium-bound complex is then eliminated in feces, effectively lowering serum potassium without systemic absorption.

Approved indications

Common side effects

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