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Sodium picosulphate/magnesium Citrate
Sodium picosulphate acts as an osmotic laxative that draws water into the colon, while magnesium citrate provides additional osmotic effect to promote bowel evacuation.
Sodium picosulphate acts as an osmotic laxative that draws water into the colon, while magnesium citrate provides additional osmotic effect to promote bowel evacuation. Used for Bowel cleansing prior to colonoscopy, Bowel cleansing prior to radiological examination of the colon.
At a glance
| Generic name | Sodium picosulphate/magnesium Citrate |
|---|---|
| Also known as | Citrafleet |
| Sponsor | Luigi Sacco University Hospital |
| Drug class | Osmotic laxative / bowel cleanser |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Sodium picosulphate is a prodrug converted by colonic bacteria to bis-(p-hydroxyphenyl)-pyridyl-methane, which stimulates colonic peristalsis and increases intraluminal fluid volume. Magnesium citrate acts as an osmotic agent, drawing water into the intestinal lumen to soften stool and promote evacuation. Together, these agents produce rapid bowel cleansing.
Approved indications
- Bowel cleansing prior to colonoscopy
- Bowel cleansing prior to radiological examination of the colon
Common side effects
- Nausea
- Vomiting
- Abdominal discomfort
- Headache
- Dizziness
Key clinical trials
- Study Assessing CLENPIQ as Bowel Preparation for Pediatric Colonoscopy (PHASE1, PHASE2)
- Comparing the Bowel Cleansing Efcacy of Picosulfate Sodium/ Citric Acid / Magnesium Oxide and Polyethylene Glycol: A Randomized Trial in Taiwan (NA)
- PEG-Asc Vs. SPMC for Bowel Preparation in Capsule-based Procedures (NA)
- Efficacy, Tolerance and Safety of Split Dose Bowel Preparation for Colonoscopy: 4L Polyethylene Glycol (PEG) Versus 1L Polyethylene Glycol Plus Sodium Picosulfate-magnesium Citrate (SPMC) (PHASE4)
- A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy (PHASE4)
- Comparing Sennosid A+B and Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation (PHASE4)
- TES RCT Fleet Enema vs Oral Mechanical Bowel Prep (PHASE4)
- Short-term Effects of Bowel Preparation on Gut Microbiome in Patients Undergoing Endoscopic Colon Polypectomy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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