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Sodium picosulfate + magnesium citrate
Sodium picosulfate acts as a stimulant laxative that increases intestinal motility, while magnesium citrate provides osmotic laxative effect to draw water into the bowel, together producing bowel evacuation.
Sodium picosulfate acts as a stimulant laxative that increases intestinal motility, while magnesium citrate provides osmotic laxative effect to draw water into the bowel, together producing bowel evacuation. Used for Bowel cleansing prior to colonoscopy, Bowel cleansing prior to radiological examination of the colon.
At a glance
| Generic name | Sodium picosulfate + magnesium citrate |
|---|---|
| Also known as | Citrafleet®, PSCM |
| Sponsor | Parc de Salut Mar |
| Drug class | Stimulant laxative + osmotic laxative combination |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Sodium picosulfate is a prodrug converted by colonic bacteria to bis-(p-hydroxyphenyl)-pyridyl-methane, which stimulates colonic nerves to increase peristalsis. Magnesium citrate is poorly absorbed and creates an osmotic gradient that retains water in the intestinal lumen, softening stool and promoting evacuation. The combination provides both mechanical stimulation and osmotic effect for rapid, complete bowel cleansing.
Approved indications
- Bowel cleansing prior to colonoscopy
- Bowel cleansing prior to radiological examination of the colon
Common side effects
- Nausea
- Abdominal pain or cramping
- Vomiting
- Diarrhea
- Headache
- Dizziness
Key clinical trials
- Study Assessing CLENPIQ as Bowel Preparation for Pediatric Colonoscopy (PHASE1, PHASE2)
- Comparing the Bowel Cleansing Efcacy of Picosulfate Sodium/ Citric Acid / Magnesium Oxide and Polyethylene Glycol: A Randomized Trial in Taiwan (NA)
- PEG-Asc Vs. SPMC for Bowel Preparation in Capsule-based Procedures (NA)
- Efficacy, Tolerance and Safety of Split Dose Bowel Preparation for Colonoscopy: 4L Polyethylene Glycol (PEG) Versus 1L Polyethylene Glycol Plus Sodium Picosulfate-magnesium Citrate (SPMC) (PHASE4)
- A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy (PHASE4)
- Comparing Sennosid A+B and Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation (PHASE4)
- TES RCT Fleet Enema vs Oral Mechanical Bowel Prep (PHASE4)
- Short-term Effects of Bowel Preparation on Gut Microbiome in Patients Undergoing Endoscopic Colon Polypectomy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sodium picosulfate + magnesium citrate CI brief — competitive landscape report
- Sodium picosulfate + magnesium citrate updates RSS · CI watch RSS
- Parc de Salut Mar portfolio CI