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Sodium fluoride paste
Sodium fluoride strengthens tooth enamel by forming fluorapatite, a more acid-resistant mineral that helps prevent dental caries.
Sodium fluoride strengthens tooth enamel by forming fluorapatite, a more acid-resistant mineral that helps prevent dental caries. Used for Prevention of dental caries (cavities), Fluoride supplementation for cavity prevention.
At a glance
| Generic name | Sodium fluoride paste |
|---|---|
| Also known as | NaF paste |
| Sponsor | Procter and Gamble |
| Drug class | Topical fluoride agent |
| Target | Tooth enamel hydroxyapatite |
| Modality | Small molecule |
| Therapeutic area | Dental/Oral Health |
| Phase | FDA-approved |
Mechanism of action
Fluoride ions penetrate the enamel surface and replace hydroxyl groups in hydroxyapatite crystals, creating fluorapatite, which is more resistant to demineralization by acids produced by cariogenic bacteria. This process remineralizes early enamel lesions and reduces the solubility of tooth structure, thereby inhibiting cavity formation.
Approved indications
- Prevention of dental caries (cavities)
- Fluoride supplementation for cavity prevention
Common side effects
- Dental fluorosis (mild, from ingestion during tooth development)
- Nausea or gastrointestinal upset (if swallowed in large amounts)
- Allergic reactions (rare)
Key clinical trials
- Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics (NA)
- Laser Therapy for Dentin Hypersensitivity (NA)
- Effect of Gluma and Bioactive Glass Desensitizers in Treatment of Dentin Hypersensitivity in Cervical Non-Carious Lesions (NA)
- Comparative Effectiveness of Remineralization Agents on Attachment-Associated Demineralization in Clear Aligner Patients (NA)
- Hydroxyapatite vs Fluoride Toothpaste for MIH Remineralization (PHASE2)
- Color Stability of S-PRG Resin-Based Light-Cure Varnish and Prophylaxis Paste on White Spot Lesions (NA)
- Clinical Evaluation of Remineralizing Potential of Remineralizing Agents on WSLs Managment (NA)
- Remineralization Effect Of Egg Shell Versus Fluoride Varnish On Early Carious White Spot Lesions In Primary Teeth (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sodium fluoride paste CI brief — competitive landscape report
- Sodium fluoride paste updates RSS · CI watch RSS
- Procter and Gamble portfolio CI