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Sodium Fluoride (NaF)
Sodium fluoride strengthens tooth enamel and bone by incorporating fluoride ions into the mineral matrix, increasing resistance to demineralization and promoting remineralization.
Sodium fluoride strengthens tooth enamel and bone by incorporating fluoride ions into the mineral matrix, increasing resistance to demineralization and promoting remineralization. Used for Osteoporosis treatment and prevention, Dental caries prevention, Fluorosis management in endemic regions.
At a glance
| Generic name | Sodium Fluoride (NaF) |
|---|---|
| Also known as | fluoride |
| Sponsor | GlaxoSmithKline |
| Drug class | Mineral supplement / Bone-active agent |
| Target | Hydroxyapatite crystal structure; bacterial glycolytic enzymes |
| Modality | Small molecule |
| Therapeutic area | Dental health / Bone metabolism / Osteoporosis |
| Phase | Phase 3 |
Mechanism of action
Fluoride ions substitute for hydroxyl groups in hydroxyapatite crystals of enamel and bone, creating fluorapatite, which is more resistant to acid attack and caries formation. This mechanism also enhances osteoblast activity and bone mineralization, making it useful in osteoporosis treatment. The fluoride ion directly inhibits glycolysis in cariogenic bacteria, providing an additional antimicrobial benefit.
Approved indications
- Osteoporosis treatment and prevention
- Dental caries prevention
- Fluorosis management in endemic regions
Common side effects
- Gastrointestinal upset (nausea, vomiting, abdominal pain)
- Dental fluorosis
- Skeletal fluorosis (chronic high-dose exposure)
- Headache
- Hypocalcemia
Key clinical trials
- Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion (PHASE3)
- Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics (NA)
- Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer (PHASE2)
- Antiplaque Efficacy and Patient Reported Outcome of Chlorohexidine, Cetylpyridinium Chloride, and Essential Oil Mouthwashes in Orthodontic Patients (NA)
- Investigation of Colgate Dual Zinc Toothpaste as Compared to Colgate Cavity Protection Toothpaste in Controlling Plaque and Gingivitis (PHASE3)
- Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash (EARLY_PHASE1)
- Hypersensitivity Reduction Efficacy: 5% Potassium Nitrate Toothpaste Compared to Colgate Cavity Protection Toothpaste (PHASE3)
- Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis. (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |