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sodium fluoride calcium fluoride
sodium fluoride calcium fluoride is a Fluoride supplement / dental caries preventive Small molecule drug developed by University of Pernambuco. It is currently FDA-approved for Dental caries prevention, Enamel remineralization, Bone health supplementation. Also known as: Duofluorid XII®, FGM, Joinville, Brazil.
Sodium fluoride and calcium fluoride work together to strengthen tooth enamel and bone by promoting fluorapatite formation and inhibiting demineralization.
Sodium fluoride and calcium fluoride work together to strengthen tooth enamel and bone by promoting fluorapatite formation and inhibiting demineralization. Used for Dental caries prevention, Enamel remineralization, Bone health supplementation.
At a glance
| Generic name | sodium fluoride calcium fluoride |
|---|---|
| Also known as | Duofluorid XII®, FGM, Joinville, Brazil |
| Sponsor | University of Pernambuco |
| Drug class | Fluoride supplement / dental caries preventive |
| Target | Hydroxyapatite crystal structure; bacterial glycolytic enzymes |
| Modality | Small molecule |
| Therapeutic area | Dentistry / Preventive oral health |
| Phase | FDA-approved |
Mechanism of action
Fluoride ions replace hydroxyl groups in hydroxyapatite crystals, forming more acid-resistant fluorapatite that resists dental caries. Calcium fluoride provides a sustained-release reservoir of fluoride ions in the oral cavity. Together, these agents enhance remineralization of early enamel lesions and reduce bacterial acid production by inhibiting glycolytic enzymes in cariogenic bacteria.
Approved indications
- Dental caries prevention
- Enamel remineralization
- Bone health supplementation
Common side effects
- Dental fluorosis (mild)
- Gastrointestinal upset
- Nausea
Key clinical trials
- Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics (NA)
- Diode Laser Plus CPP-ACPF vs CPP-ACPF Alone for Dentin Hypersensitivity (NA)
- Effect of Gluma and Bioactive Glass Desensitizers in Treatment of Dentin Hypersensitivity in Cervical Non-Carious Lesions (NA)
- Effect Of Silverdiamine Fluoride Gel, Sodium Fluoride With CPP-ACP, APF On Early Childhood Caries - A Randomised Controlled Trial (PHASE2)
- A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching (PHASE4)
- Pulmonary Rehabilitation in Salt Chambers for Patients With COPD (NA)
- Comparative Effectiveness of Remineralization Agents on Attachment-Associated Demineralization in Clear Aligner Patients (NA)
- A Clinical Study to Evaluate the Anti-Sensitivity Effect of a Calcium Sodium Phosphosilicate Toothpaste in a Population of Dentin Hypersensitivity Sufferers (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- sodium fluoride calcium fluoride CI brief — competitive landscape report
- sodium fluoride calcium fluoride updates RSS · CI watch RSS
- University of Pernambuco portfolio CI
Frequently asked questions about sodium fluoride calcium fluoride
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Related
- Drug class: All Fluoride supplement / dental caries preventive drugs
- Target: All drugs targeting Hydroxyapatite crystal structure; bacterial glycolytic enzymes
- Manufacturer: University of Pernambuco — full pipeline
- Therapeutic area: All drugs in Dentistry / Preventive oral health
- Indication: Drugs for Dental caries prevention
- Indication: Drugs for Enamel remineralization
- Indication: Drugs for Bone health supplementation
- Also known as: Duofluorid XII®, FGM, Joinville, Brazil
- Compare: sodium fluoride calcium fluoride vs similar drugs
- Pricing: sodium fluoride calcium fluoride cost, discount & access